[18F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models

详细信息    查看全文

• 作者：Sarah G. J. A. Peeters ; Ludwig Dubois ; Natasja G. Lieuwes&#8230
• 关键词：[18F]VM4 ; 037 ; CAIX ; PET imaging ; Biodistribution ; Preclinical
• 刊名：Molecular Imaging and Biology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：17
• 期：5
• 页码：615-619
• 全文大小：628 KB
• 参考文献：1.Wykoff CC, Beasley NJ, Watson PH et al (2000) Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60:7075鈥?083PubMed
  2.Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393鈥?10CrossRef PubMed
  3.Lendahl U, Lee KL, Yang H, Poellinger L (2009) Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet 10:821鈥?32CrossRef PubMed
  4.Svastova E, Hulikova A, Rafajova M et al (2004) Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 577:439鈥?45CrossRef PubMed
  5.Generali D, Berruti A, Brizzi MP et al (2006) Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12:4562鈥?568CrossRef PubMed
  6.Supuran CT, Dedhar S (2012) Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 3:84鈥?7PubMed Central PubMed
  7.Dubois L, Peeters SG, van Kuijk SJ et al (2013) Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs. Radiother Oncol 108:523鈥?28CrossRef PubMed
  8.Dubois L, Peeters S, Lieuwes NG et al (2011) Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiother Oncol 99:424鈥?31CrossRef PubMed
  9.Pacchiano F, Carta F, McDonald PC et al (2011) Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem 54:1896鈥?902CrossRef PubMed
  10.Svastova E, Witarski W, Csaderova L et al (2012) Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain. J Biol Chem 287:3392鈥?402PubMed Central CrossRef PubMed
  11.Lou Y, McDonald PC, Oloumi A et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res 71:3364鈥?376CrossRef PubMed
  12.Doss M, Kolb HC, Walsh JC et al (2014) Biodistribution and radiation dosimetry of the carbonic anhydrase IX imaging agent [(18) F]VM4-037 determined from PET/CT scans in healthy volunteers. Mol Imaging Biol 16:739鈥?46CrossRef PubMed
  13.Aerts HJ, Dubois L, Perk L et al (2009) Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET. J Nucl Med 50:123鈥?31CrossRef PubMed
  14.Dubois L, Douma K, Supuran CT et al (2007) Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother Oncol 83:367鈥?73CrossRef PubMed
  15.Innocenti A, Vullo D, Scozzafava A, Supuran CT (2005) Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett 15:567鈥?71CrossRef PubMed
  16.Metwalli AR, Turkbey B, McKinney Y, et al (2014) Results of a phase II trial of novel carbonic anhydrase IX radiotracer 18F-VM4-037 in renal cell carcinoma. In 2014 Genitourinary Cancer Symposium. San Francisco
  17.Zhao Z, Liao G, Li Y, Zhou S et al (2014) Prognostic value of carbonic anhydrase IX immunohistochemical expression in renal cell carcinoma: a meta-analysis of the literature. PLoS ONE 9:e114096PubMed Central CrossRef PubMed
  18.Liu Z, Pourghiasian M, Radtke MA et al (2014) An organotrifluoroborate for broadly applicable one-step (18) f-labeling. Angew Chem 53:11876鈥?1880CrossRef
  19.Honarvar H, Garousi J, Gunneriusson E et al (2015) Imaging of CAIX-expressing xenografts in vivo using 99mTc-HEHEHE-ZCAIX:1 Affibody molecule. Int J Oncol 46:513鈥?20PubMed Central PubMed
  
• 作者单位：Sarah G. J. A. Peeters (1)
  Ludwig Dubois (1)
  Natasja G. Lieuwes (1)
  Dennis Laan (2)
  Martien Mooijer (2)
  Robert C. Schuit (2)
  Daniela Vullo (3)
  Claudiu T. Supuran (3)
  Jonas Eriksson (2)
  Albert D. Windhorst (2)
  Philippe Lambin (1)
  
  1. Department of Radiation Oncology (MaastRO Lab), GROW鈥擲chool for Oncology and Developmental Biology, Maastricht University Medical Centre, UNS 50/23, PO Box 616, 6200 MD, Maastricht, The Netherlands
  2. Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1081 HV, Amsterdam, The Netherlands
  3. Neurofarba Department, Sezione di Scienze Farmaceutiche and Laboratorio di Chimica Bioinorganica, Universit脿 degli Studi di Firenze, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
  
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002

文摘

Purpose [18F]VM4-037 was recently developed as a positron emission tomography (PET) tracer for the detection of carbonic anhydrase IX (CAIX), a tumor-specific protein upregulated under hypoxic conditions. In this study, the accumulation of [18F]VM4-037 was determined in two CAIX-expressing preclinical human tumor models.