Role of PSA density in diagnosis of prostate cancer in obese men

详细信息    查看全文

• 作者：Peter Ka-Fung Chiu (1)
  Jeremy Yuen-Chun Teoh (1)
  Samson Yun-Sang Chan (1)
  Peggy Sau-Kwan Chu (2)
  Chi-Wai Man (2)
  See-Ming Hou (1)
  Chi-Fai Ng (1)
  
• 关键词：Prostate ; specific antigen ; Prostate cancer ; Obesity
• 刊名：International Urology and Nephrology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：46
• 期：12
• 页码：2251-2254
• 全文大小：162 KB
• 参考文献：1. Swinburn BA, Sacks G, Hall KD et al (2011) The global obesity pandemic: shaped by global drivers and local environments. Lancet 378(9793):804-14 CrossRef
  2. World Health Organization Expert Consultation (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363(9403):157-63 CrossRef
  3. Buschemeyer WC 3rd, Freedland SJ (2007) Obesity and prostate cancer: epidemiology and clinical implications. Eur Urol 52(2):331-43 CrossRef
  4. Dahle SE, Chokkalingam AP, Gao YT et al (2002) Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia. J Urol 168(2):599-04 CrossRef
  5. Freedland SJ, Platz EA, Presti JC et al (2006) Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol 175(2):500-04 CrossRef
  6. Grubb RL 3rd, Black A, Izmirlian G et al (2009) Serum prostate-specific antigen hemodilution among obese men undergoing screening in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomark Prev 18(3):748-51 CrossRef
  7. Ohwaki K, Endo F, Muraishi O et al (2010) Relationship between prostate-specific antigen and hematocrit: does hemodilution lead to lower PSA concentrations in men with a higher body mass index? Urology 75(3):648-52 CrossRef
  8. Chiu PK, Wong AY, Hou SM et al (2011) Effect of body mass index on prostate-specific antigen levels among patients presented with lower urinary tract symptoms. Asian Pac J Cancer Prev 12(8):1937-940
  9. Freedland SJ, Aronson WJ, Kane CJ et al (2004) Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group. J Clin Oncol 22(3):446-53 CrossRef
  10. Strom SS, Kamat AM, Gruschkus SK et al (2006) Influence of obesity on biochemical and clinical failure after external beam radiotherapy for localized prostate cancer. Cancer 107(3):631-39 CrossRef
  11. Benson MC, Whang IS, Pantuck A et al (1992) Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol 147(3 Pt 2):815-16
  12. Bazinet M, Meshref AW, Trudel C et al (1994) Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology 43(1):44-1 CrossRef
  13. Djavan B, Remzi M, Zlotta AR et al (2002) Complexed prostate-specific antigen, complexed prostate-specific antigen density of total and transition zone, complexed/total prostate-specific antigen ratio, free-to-total prostate-specific antigen ratio, density of total and transition zone prostate-specific antigen: results of the prospective multicenter European trial. Urology 60(4 Suppl 1):4- CrossRef
  14. Bazinet M, Meshref AW, Trudel C et al (1994) Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology 43(1):44-1 CrossRef
  15. Catalona WJ, Richie JP, deKernion JB et al (1994) Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves. J Urol 152(6 Pt 1):2031-036
  16. Andersson SO, Wolk A, Bergstrom R et al (1997) Body size and prostate cancer: a 20-year follow-up study among 1350
• 作者单位：Peter Ka-Fung Chiu (1)
  Jeremy Yuen-Chun Teoh (1)
  Samson Yun-Sang Chan (1)
  Peggy Sau-Kwan Chu (2)
  Chi-Wai Man (2)
  See-Ming Hou (1)
  Chi-Fai Ng (1)
  
  1. SH Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong
  2. Department of Surgery, Tuen Mun Hospital, Tuen Mun, Hong Kong
  
• ISSN：1573-2584

文摘

Purpose To compare the performance of prostate-specific antigen (PSA) density in the diagnosis of prostate cancer in obese and non-obese Chinese men. Methods The results of transrectal ultrasound-guided (TRUS) prostate biopsies of Chinese men with PSA 0.15?ng/mL as positive) in obese and non-obese men with PSA 2 according to WHO recommendation for Hong Kong Chinese. Results TRUS biopsy, BMI, and PSA density data were available for 854 men (mean age 65.9?±?7.3). The mean PSA values for the obese and non-obese patients were 7.9?±?3.7 and 8.2?±?4.1?ng/mL, respectively (p?=?0.416). TRUS volumes in obese and non-obese men were 63.2?ml and 51.6?ml, respectively (t test, p?p?p?p?=?0.001) in non-obese men. The specificity and area under the curve of PSA density were 74.2?% and 0.731, respectively, for obese men, and 51.4?% and 0.653, respectively, for non-obese men. Among patients with a diagnosis of prostate cancer, the obese patient group had a significantly higher proportion of patients with Gleason 7-0 prostate cancer than the non-obese patient group (48.9 vs. 32.7?%, Chi-square test, p?=?0.035), and a trend toward a higher proportion of bilateral lobe involvement. Conclusion PSA density had better performance in obese men. Positive PSA density in obese men was associated with four times the risk of prostate cancer.