Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype–clinical syndrome association and risk factors for lower respiratory tract infection
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- 作者：Shuk-Kuen Chau (1)
So-lun Lee (1)
Malik J. S. Peiris (2)
Kwok-Hung Chan (3)
Eunice Chan (1)
Wilfred Wong (1)
Susan S. Chiu (1) - 关键词：Adenovirus ; Children ; Hong Kong ; Respiratory tract infection ; Risk factors ; Serotypes
- 刊名：European Journal of Pediatrics
- 出版年：2014
- 出版时间：March 2014
- 年：2014
- 卷：173
- 期：3
- 页码：291-301
- 全文大小：255 KB
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So-lun Lee (1)
Malik J. S. Peiris (2)
Kwok-Hung Chan (3)
Eunice Chan (1)
Wilfred Wong (1)
Susan S. Chiu (1)
1. Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
2. The School of Public Health, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong SAR
3. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong SAR - ISSN：1432-1076
文摘
Lower respiratory tract infections (LRTI) caused by adenovirus can be severe with resultant chronic pulmonary sequelae. More than 50 serotypes have been recognized; however, the exact association of serotype with clinical phenotype is still unclear. There have been no reports on the adenovirus serotype pattern in Hong Kong, and their relationships with disease manifestations and complications are not known. Clinical and epidemiological data on 287 children (<6?years old) admitted with adenovirus respiratory infections from 2001 to 2004 were reviewed. Common presenting symptoms included fever (97.9?%) and cough and rhinitis (74?%). Extra-pulmonary manifestations were present in 37.3?%. The clinical picture mimicked bacterial infection for its prolonged high fever and neutrophilic blood picture. Forty-two patients (14.6?%) had LRTI, either pneumonia or acute bronchiolitis, but none had severe acute respiratory compromise. Children aged 1 to 2?years old were most at risk for adenovirus LRTI (adjusted p--.0165). Serotypes 1 to 7 could be identified in 93.7?% of the nasopharyngeal specimens, with serotypes 2 and 3 being the most prevalent. Different serotypes showed predilection for different age groups and with different respiratory illness association. The majority of acute bronchiolitis (71.4?%) were associated with serotype 2 infection, and this association was statistically significant (p-lt;-.0001). Serotype 3 infection accounted for over half of the pneumonia cases (57-5?%) in those aged 3-?years old. Only one patient developed mild bronchiectasis after serotype 7 pneumonia. Children aged 1 to 2?years old were the at-risk group for adenovirus LRTI, but respiratory morbidity was relatively mild in our locality. There was an apparent serotype–respiratory illness association.