The Effects of Amiloride on Seizure Activity, Cognitive Deficits and Seizure-Induced Neurogenesis in a Novel Rat Model of Febrile Seizures

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• 作者：Tang-Peng Ou-Yang ; Ge-Min Zhu ; Yin-Xiu Ding ; Feng Yang…
• 关键词：Sodium–hydrogen exchangers ; Amiloride ; Febrile seizures ; Neurogenesis
• 刊名：Neurochemical Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：41
• 期：4
• 页码：933-942
• 全文大小：1,988 KB
• 参考文献：1.Jeong JH, Lee JH, Kim K, Jo YH, Rhee JE, Kwak YH, Kim DK, Noh H (2014) Rate of and risk factors for early recurrence in patients with febrile seizures. Pediatr Emerg Care 30:540–545CrossRef PubMed
  2.Seinfeld DS, Pellock JM (2013) Recent research on febrile seizures: a review. J Neurol Neurophysiol 4:1–14
  3.Patterson JL, Carapetian SA, Hageman JR, Kelley KR (2013) Febrile seizures. Pediatr Ann 42:249–254CrossRef PubMed
  4.Fetveit A (2008) Assessment of febrile seizures in children. Eur J Pediatr 167:17–27CrossRef PubMed
  5.Pediatrics AAo (2011) Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics 127:389CrossRef
  6.Martinos MM, Yoong M, Patil S, Chin RF, Neville BG, Scott RC, de Haan M (2012) Recognition memory is impaired in children after prolonged febrile seizures. Brain 135:3153–3164CrossRef PubMed PubMedCentral
  7.Yang L, Li F, Zhang H, Ge W, Mi C, Sun R, Liu C (2009) Astrocyte activation and memory impairment in the repetitive febrile seizures model. Epilepsy Res 86:209–220CrossRef PubMed
  8.Chang YC, Huang AM, Kuo YM, Wang ST, Chang YY, Huang CC (2003) Febrile seizures impair memory and cAMP response-element binding protein activation. Ann Neurol 54:706–718CrossRef PubMed
  9.Millar JS (2006) Evaluation and treatment of the child with febrile seizure. Am Fam Physician 73:1761–1764PubMed
  10.Wheless JW, Clarke DF, Carpenter D (2005) Treatment of pediatric epilepsy: expert opinion, 2005. J Child Neurol 20(Suppl 1):S1–S56PubMed
  11.Bergman DA, Baltz RD, Cooley JR, Hickson GB, Miles PV, Shook JE, Zurhellen WM (1999) Practice parameter: long-term treatment of the child with simple febrile seizures. Pediatrics 103:1307–1309CrossRef
  12.Shinnar S, Glauser TA (2002) Febrile seizures. J Child Neurol 17(Suppl 1):S44–S52CrossRef PubMed
  13.Simonato M, French JA, Galanopoulou AS, O’Brien TJ (2013) Issues for new antiepilepsy drug development. Curr Opin Neurol 26:195CrossRef PubMed PubMedCentral
  14.Ali A, Ahmad F, Dua Y, Pillai K, Vohora D (2008) Seizures and sodium hydrogen exchangers: potential of sodium hydrogen exchanger inhibitors as novel anticonvulsants. CNS Neurol Disord Drug Targets 7:343–347CrossRef PubMed
  15.Villafuerte FC, Swietach P, Youm JB, Ford K, Cardenas R, Supuran CT, Cobden PM, Rohling M, Vaughan-Jones RD (2014) Facilitation by intracellular carbonic anhydrase of Na+–HCO3− co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte. J Physiol 592:991–1007CrossRef PubMed PubMedCentral
  16.Verma V, Bali A, Singh N, Jaggi AS (2015) Implications of sodium hydrogen exchangers in various brain diseases. J Basic Clin Physiol Pharmacol 26:417–426CrossRef PubMed
  17.N’Gouemo P (2008) Amiloride delays the onset of pilocarpine-induced seizures in rats. Brain Res 1222:230–232. doi:10.​1016/​j.​brainres.​2008.​05.​010 CrossRef PubMed PubMedCentral
  18.Luszczki J, Czernecki R, Wojtal K, Borowicz K, Czuczwar S (2008) Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. J Neural Trans 115:1485–1494. doi:10.​1007/​s00702-008-0046-3 CrossRef
  19.Ali A, Ahmad FJ, Pillai KK, Vohora D (2004) Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior. Epilepsy Behav 5:322–328. doi:10.​1016/​j.​yebeh.​2004.​01.​005 CrossRef PubMed
  20.Shapiro LA, Ribak CE, Jessberger S (2008) Structural changes for adult-born dentate granule cells after status epileptic us. Epilepsia 49:13–18CrossRef PubMed
  21.Eghbal-Ahmadi M, Avishai-Eliner S, Hatalski CG, Baram TZ (1999) Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J Neurosci 19:3982–3991PubMed PubMedCentral
  22.Baram TZ, Gerth A, Schultz L (1997) Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res Dev Brain Res 98:265–270CrossRef PubMed PubMedCentral
  23.Schuchmann S, Schmitz D, Rivera C, Vanhatalo S, Salmen B, Mackie K, Sipilä ST, Voipio J, Kaila K (2006) Experimental febrile seizures are precipitated by a hyperthermia induced respiratory alkalosis. Nat Med 12:817–823CrossRef PubMed PubMedCentral
  24.Sarkisian MR, Holmes GL, Carmant L, Liu Z, Yang Y, Stafstrom CE (1999) Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain. Brain Dev 21:318–325CrossRef PubMed
  25.Prévost F, Costa M, Carmant L, Lepore F, Guillemot J-P (2010) Effects of hyperthermic seizures on the developing primary visual cortex of the rat. Neuroscience 171:1120–1130CrossRef PubMed
  26.Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP (2004) Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 118:687–698. doi:10.​1016/​j.​cell.​2004.​08.​026 CrossRef PubMed
  27.Chesler M, Kaila K (1992) Modulation of pH by neuronal activity. Trends Neurosci 15:396–402CrossRef PubMed
  28.Yao H, Ma E, Gu XQ, Haddad GG (1999) Intracellular pH regulation of CA1 neurons in Na+/H+ isoform 1 mutant mice. J Clin Invest 104:637–645. doi:10.​1172/​JCI6785 CrossRef PubMed PubMedCentral
  29.Puka N, Lehmann A (1994) In vivo acidosis reduces extracellular concentrations of taurine and glutamate in the rat hippocampus. J Neurosci Res 37:641–646CrossRef PubMed
  30.Chu XP, Xiong ZG (2012) Physiological and pathological functions of acid-sensing ion channels in the central nervous system. Curr Drug Targets 13:263–271CrossRef PubMed PubMedCentral
  31.Rajab E, Abdeen Z, Hassan Z, Alsaffar Y, Mandeel M, Al Shawaaf F, Al-Ansari S, Kamal A (2014) Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. Int J Dev Neurosci 34:19–23CrossRef PubMed
  32.Xiong Y, Zhou H, Zhang L (2014) Influences of hyperthermia-induced seizures on learning, memory and phosphorylative state of CaMKII α in rat hippocampus. Brain Res 1557:190–200CrossRef PubMed
  33.Tsai ML, Hung KL, Tsan YY, Tung WT (2015) Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children. Epilepsy Behav 47:55–60. doi:10.​1016/​j.​yebeh.​2015.​04.​067 CrossRef PubMed
  34.Jessberger S, Nakashima K, Clemenson GD Jr, Mejia E, Mathews E, Ure K, Ogawa S, Sinton CM, Gage FH, Hsieh J (2007) Epigenetic modulation of seizure-induced neurogenes is and cognitive decline. J Neurosci 27:5967–5975CrossRef PubMed
  35.Chena J, Quana Q-Y, Yang F, Wang Y, Wang J-C, Zhao G, Jiang W (2010) Effects of lamotrigine and topiramate on hippocampal neurogenesis in experimental temporal-lobe epilepsy. Brain Res 1313:270–282CrossRef
  36.Bender RA, Dubé C, Gonzalez-Vega R, Mina EW, Baram TZ (2003) Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus 13:399–412CrossRef PubMed PubMedCentral
  37.Hung YW, Yang DI, Huang PY, Lee TS, Kuo TB, Yiu CH, Shih YH, Lin YY (2012) The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats. Epilepsy Res 98:206–215. doi:10.​1016/​j.​eplepsyres.​2011.​09.​015 CrossRef PubMed
  38.Shi X-Y, Sun R-P, Wang J-W (2007) Consequences of pilocarpine-induced recurrent seizures in neonatal rats. Brain Dev 29:157–163CrossRef
  39.Willems L, Tamburini J, Chapuis N, Lacombe C, Mayeux P, Bouscary D (2012) PI3K and mTOR signaling pathways in cancer: new data on targeted therapies. Curr Oncol Rep 14:129–138. doi:10.​1007/​s11912-012-0227-y CrossRef PubMed
  40.Tang JY, Chang HW, Chang JG (2013) Modulating roles of amiloride in irradiation-induced antiproliferative effects in glioblastoma multiforme cells involving Akt phosphorylation and the alternative splicing of apoptotic genes. DNA Cell Biol 32:504–510. doi:10.​1089/​dna.​2013.​1998 CrossRef PubMed PubMedCentral
  
• 作者单位：Tang-Peng Ou-Yang (1)
  Ge-Min Zhu (2)
  Yin-Xiu Ding (1) (3)
  Feng Yang (1)
  Xiao-Long Sun (1)
  Wen Jiang (1)
  
  1. Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, People’s Republic of China
  2. Department of Neurology, Xi’an Central Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, 710032, People’s Republic of China
  3. Department of Human Anatomy, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

Accumulating data suggest that sodium–hydrogen exchangers (NHEs) play a key role in modulating seizure activity by regulating neuronal pH in the brain. Amiloride, an inhibitor of NHEs, has been demonstrated to be effective in many seizure models, although its efficacy for prolonged febrile seizures (FS) remains unclear. In this study, we investigated whether amiloride could produce neuroprotective effects in a prolonged FS model in which FS were induced in rat pups at postnatal day 10 using a heated air approach. Amiloride was administered by intraperitoneal injection at three different doses (0.65, 1.3 and 2.6 mg/kg). Pretreatment with amiloride significantly delayed the onset of the first episode of limbic seizures, whereas posttreatment with amiloride decreased escape latency in the Morris water maze test compared to post-FS treatment with saline. Amiloride also inhibited seizure-induced aberrant neurogenesis. In conclusion, this study demonstrated the antiseizure activity of amiloride. In particular, posttreatment with amiloride resulted in cognitive improvement; this finding provides crucial evidence of the neuroprotective function of amiloride and of the therapeutic potential of amiloride in FS.