Combined detection of Gab1 and Gab2 expression predicts clinical outcome of patients with glioma
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- 作者：Hui Liu (1)
Gang Li (2)
Weitao Zeng (1)
Pengxing Zhang (1)
Feiyan Fan (1)
Yanyang Tu (1)
Yongsheng Zhang (3) - 关键词：Grb2 ; associated binder family ; Glioma ; Immunohistochemistry ; Prognosis
- 刊名：Medical Oncology
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：31
- 期：8
- 全文大小：933 KB
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Gang Li (2)
Weitao Zeng (1)
Pengxing Zhang (1)
Feiyan Fan (1)
Yanyang Tu (1)
Yongsheng Zhang (3)
1. Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China
2. Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China
3. Administrative Department, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China - ISSN：1559-131X
文摘
Grb2-associated binder 1 (Gab1) and Gab2 play important roles in cancer cell signaling. In particular, it has been demonstrated that the upregulation of Gab2 may be correlated with the World Health Organization (WHO) grade of gliomas and that patients with high Gab2 expression levels exhibited shorter survival time. However, the prognostic value of combined expression of Gab1 and Gab2 has not been explored. Gab1 and Gab2 expression in human gliomas and non-neoplastic brain tissues was measured by immunohistochemistry. Both the expression levels of Gab1 and Gab2 proteins in glioma tissues were significantly higher than those in non-neoplastic brain tissues (both P?Gab1 and Gab2 proteins were both significantly associated with advanced WHO grades (both P?P?=?0.01). Moreover, the overall survival of patients with high Gab1 protein expression or high Gab2 protein expression was obviously lower than those with low expressions (both P?Gab1 and Gab2 proteins (Gab1-high/Gab2-high) had shortest overall survival (P?Gab1 expression (P?=?0.01), Gab2 expression (P?=?0.02), and combined expression of Gab1 and Gab2 (Gab1/Gab2, P?=?0.006) were all independent prognostic factors for overall survival in glioma patients. Gab1 and Gab2 proteins are differentially expressed in glioma patients and closely correlated with the biological behavior of this malignancy. Combination of Gab1 and Gab2 expression may represent a promising biomarker for prognostication of human gliomas.