Disaccharide analysis of chondroitin and heparin from farmed Atlantic salmon
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- 作者：Ragnar Flengsrud
- 关键词：Atlantic salmon ; Chondroitin disaccharides ; Heparin disaccharides ; Heparin pentasaccharide
- 刊名：Glycoconjugate Journal
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：33
- 期：2
- 页码：121-123
- 全文大小：248 KB
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1. Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), N-1432, Ås, Norway - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Biochemistry
Pathology - 出版者：Springer Netherlands
- ISSN：1573-4986
文摘
The heparin disaccharides detected in farmed Atlantic salmon (Salmo salar) gills and intestines have, with one exception, been reported in porcine heparin. The relative amounts of disaccharides appear to be very different in the two species. Two chondroitin disaccharides with a proposed essential role in the zebrafish (Danio rerio) development and differentiation are detected in farmed Atlantic salmon. In addition, most of the chondroitin/dermatan sulfate and heparin disaccharides detected here have been reported in zebrafish, in support of the claims of the heparin presence in fish. The same chondroitin/dermatan disaccharides were detected in the bones of bony fishes. The rare disaccharide UA2S-GalNAc that was found in trace amounts in all 5 bony fishes was found in relative high amounts in gills and in significant amounts in intestines. The rare heparin disaccharide UA2S-GlcN was in relative highest amounts both in gills and intestines. In context with our previous reports, this communication suggests that glycosaminoglycans in farmed Atlantic salmon heparin need further studies in order to clarify structure and function.