Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals
详细信息 查看全文
- 作者：Gabriela Silveira-Nunes ; Elaine Speziali ; Andréa Teixeira-Carvalho…
- 关键词：Aging ; Cytokine ; Adaptive immune cells ; Innate immune cells
- 刊名：Immunity & Ageing
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1516KB
- 刊物主题：Immunology; Geriatrics/Gerontology; Aging; Public Health; Clinical Nutrition; Antibodies;
- 出版者：BioMed Central
- ISSN：1742-4933
- 卷排序：14
文摘
BackgroundImmunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian individuals was studied. We analysed frequencies of cytokine-producing lymphocytes and innate immune cells from individuals at several ages spanning a lifetime period (0–85 years).