Changes in presepsin concentrations in surgical patients with end-stage kidney disease undergoing living kidney transplantation: a pilot study

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• 作者：Junichi Saito ; Eiji Hashiba ; Tetsuya Kushikata ; Akio Mikami…
• 关键词：Presepsin ; Procalcitonin ; Living kidney transplantation ; End ; stage kidney disease
• 刊名：Journal of Anesthesia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：30
• 期：1
• 页码：174-177
• 全文大小：673 KB
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• 作者单位：Junichi Saito (1)
  Eiji Hashiba (2)
  Tetsuya Kushikata (1)
  Akio Mikami (3)
  Kazuyoshi Hirota (1)
  
  1. Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan
  2. Division of Intensive Care Unit, Hirosaki University Hospital, Hirosaki, Japan
  3. Central Clinical Laboratory, Hirosaki University Hospital, Hirosaki, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359

文摘

Presepsin is a useful marker for differentiating sepsis from non-infection-related systemic inflammatory response syndrome. There are data describing elevated presepsin concentrations in patients with kidney dysfunction even in the absence of sepsis, but corresponding data for patients with end-stage kidney disease (ESKD) undergoing living kidney transplantation (LKT) are lacking. We investigated the changes in presepsin concentrations in this patient group in order to elucidate any relationship with renal function. Written informed consent was obtained from patients with ESKD requiring hemodialysis who underwent LKT from June 2014 through March 2015 at Hirosaki University Hospital. Patients with obvious signs of infection were excluded. Perioperative presepsin and procalcitonin concentrations were measured before induction of anesthesia, on admission to the intensive care unit after surgery, and on postoperative day (POD) 1 and POD 2. Preoperative presepsin concentration was markedly higher than the upper limit of normal in patients with ESKD (1252 ± 451 pg/mL). Presepsin concentrations consistently decreased after LKT. Moreover, presepsin concentration was strongly correlated with serum creatinine (r 2 = 0.72, n = 24, p < 0.001). These data suggest that the kidney clearly plays an important role in the metabolism and excretion of presepsin. Keywords Presepsin Procalcitonin Living kidney transplantation End-stage kidney disease