Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep

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• 作者：Rohana P. Dassanayake ; Sally A. Madsen-Bouterse…
• 关键词：Bioassay ; Classical scrapie ; Lambs ; Monocytes ; T lymphocytes
• 刊名：BMC Veterinary Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：1
• 全文大小：579 KB
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• 作者单位：Rohana P. Dassanayake (1)
  Sally A. Madsen-Bouterse (1)
  Thomas C. Truscott (2)
  Dongyue Zhuang (2)
  Michelle R. Mousel (2)
  William C. Davis (1)
  David A. Schneider (1) (2)
  
  1. Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-6630, USA
  2. Animal Disease Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, WA, 99164-6630, USA
  
• 刊物主题：Veterinary Medicine; Zoology; Transgenics;
• 出版者：BioMed Central
• ISSN：1746-6148

文摘

Background Classical scrapie is a transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Our previous bioassay studies in lambs revealed that scrapie prions could be detected in association with peripheral blood monocular cells (PBMC), B lymphocytes and platelet-rich plasma fractions. In the present study, bioassay in lambs was again used to determine if scrapie prions are associated with the other two subsets of PBMC, monocytes and T lymphocytes.