The role of Toll-like receptor 4 in high-glucose-induced inflammatory and fibrosis markers in human peritoneal mesothelial cells
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- 作者：Soon-Youn Choi ; Hye-Myung Ryu ; Ji-Young Choi…
- 关键词：Toll ; like receptors ; Human peritoneal mesothelial cells ; Peritoneal fibrosis ; Peritoneal dialysis
- 刊名：International Urology and Nephrology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：49
- 期：1
- 页码：171-181
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Nephrology; Urology;
- 出版者：Springer Netherlands
- ISSN：1573-2584
- 卷排序：49
文摘
PurposeHigh glucose stimulates peritoneal inflammation and extracellular matrix accumulation in human peritoneal mesothelial cells (HPMCs). However, the roles of Toll-like receptor 4 (TLR4) and TLR2 in high-glucose-induced inflammation and fibrosis in peritoneal dialysis (PD) remain unclear. This study aimed to evaluate the effect of high glucose on TLR2 and TLR4 expression in HPMCs and to assess their impact on peritoneal inflammatory and fibrosis markers.