A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

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• 作者：Petra Willems ; Kim De Ruyck ; Rudy Van den Broecke ; Amin Makar ; Gianpaolo Perletti ; Hubert Thierens and Anne Vral
• 关键词：Double strand break (DSB) repair ; Non ; homologous end ; joining (NHEJ) ; Ku70/XRCC6 ; Breast cancer ; Hormone exposure ; Single nucleotide polymorphism (SNP)
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2009
• 出版时间：September, 2009
• 年：2009
• 卷：135
• 期：9
• 页码：1159-1168
• 全文大小：499.7 KB

文摘

Purpose Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C>G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined.