Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physicochemical characterization, and in vitro skin permeation studies

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• 作者：Geun Young Noh ; Ji Young Suh ; Soo Nam Park
• 关键词：Nanostructured Lipid Carrier ; Transdermal Delivery System ; Ceramide ; Isoliquiritigenin ; MEL
• 刊名：Korean Journal of Chemical Engineering
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：2
• 页码：400-406
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Industrial Chemistry/Chemical Engineering; Catalysis; Materials Science, general; Biotechnology;
• 出版者：Springer US
• ISSN：1975-7220
• 卷排序：34

文摘

An optimized, ceramide-based, nanostructured lipid carrier (NLC) formulation was developed for isoliquiritigenin (ILTG), and its potential as a transdermal delivery system was evaluated. ILTG-loaded NLCs were prepared by blending solid (ceramide, cholesterol) and liquid lipids (caprylic/capric triglyceride) in various proportions using a hot homogenization and ultrasonication method. The physicochemical characteristics were investigated by DLS, ZP, EE%, TEM, DSC and XRD analyses and in vitro skin permeation studies. The results showed that the particle size of the formulation was 150.19–251.69 nm with a ZP>−20mV. The EE% was 56.45–89.97%. The NLC structure was influenced by lipid ratio, and increasing the caprylic/capric triglyceride ratio caused a less ordered structure, as confirmed by DSC. The XRD analysis indicated that ILTG was not in the crystalline state in all formulations. The skin permeation study showed that the ILTG-NLCs promoted ILTG permeation. In conclusion, ceramide-based NLCs could be a promising vehicle for the ILTG transdermal delivery of ILTG.