Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo

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• 作者：Aurore Thélie (1) (2) (3) (4)
  Pascal Papillier (1) (2) (3) (4)
  Sophie Pennetier (1) (2) (3) (4) (5)
  Christine Perreau (1) (2) (3) (4)
  Juan Martin Traverso (1) (2) (3) (4)
  Svetlana Uzbekova (1) (2) (3) (4)
  Pascal Mermillod (1) (2) (3) (4)
  Catherine Joly (6)
  Patrice Humblot (7)
  Rozenn Dalbiès-Tran (1) (2) (3) (4)
  
• 刊名：BMC Developmental Biology
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：7
• 期：1
• 全文大小：382KB
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• 作者单位：Aurore Thélie (1) (2) (3) (4)
  Pascal Papillier (1) (2) (3) (4)
  Sophie Pennetier (1) (2) (3) (4) (5)
  Christine Perreau (1) (2) (3) (4)
  Juan Martin Traverso (1) (2) (3) (4)
  Svetlana Uzbekova (1) (2) (3) (4)
  Pascal Mermillod (1) (2) (3) (4)
  Catherine Joly (6)
  Patrice Humblot (7)
  Rozenn Dalbiès-Tran (1) (2) (3) (4)
  
  1. INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France
  2. CNRS, UMR6175, F-37380, Nouzilly, France
  3. Université de Tours, F-37041, Tours, France
  4. Haras Nationaux, F-37380, Nouzilly, France
  5. Centre de Recherche en Biologie de la Reproduction, Département des Sciences Animales, Université Laval, G1K 7P4, Québec, Canada
  6. Union Nationale des Coopératives d'Elevage et d'Insémination Animale, station UNCEIA/UCEAR, F-38300, Chateauvillain, France
  7. Département R&D, Union Nationale des Coopératives d'Elevage et d'Insémination Animale, F-94703, Maisons-Alfort, France
  

文摘

Background In bovine maturing oocytes and cleavage stage embryos, gene expression is mostly controlled at the post-transcriptional level, through degradation and deadenylation/polyadenylation. We have investigated how post transcriptional control of maternal transcripts was affected during in vitro and in vivo maturation, as a model of differential developmental competence. Results Using real time PCR, we have analyzed variation of maternal transcripts, in terms of abundance and polyadenylation, during in vitro or in vivo oocyte maturation and in vitro embryo development. Four genes are characterized here for the first time in bovine: ring finger protein 18 (RNF18) and breast cancer anti-estrogen resistance 4 (BCAR4), whose oocyte preferential expression was not previously reported in any species, as well as Maternal embryonic leucine zipper kinase (MELK) and STELLA. We included three known oocyte marker genes (Maternal antigen that embryos require (MATER), Zygote arrest 1 (ZAR1), NACHT, leucine rich repeat and PYD containing 9 (NALP9)). In addition, we selected transcripts previously identified as differentially regulated during maturation, peroxiredoxin 1 and 2 (PRDX1, PRDX2), inhibitor of DNA binding 2 and 3 (ID2, ID3), cyclin B1 (CCNB1), cell division cycle 2 (CDC2), as well as Aurora A (AURKA). Most transcripts underwent a moderate degradation during maturation. But they displayed sharply contrasted deadenylation patterns that account for variations observed previously by DNA array and correlated with the presence of a putative cytoplasmic polyadenylation element in their 3' untranslated region. Similar variations in abundance and polyadenylation status were observed during in vitro maturation or in vivo maturation, except for PRDX1, that appears as a marker of in vivo maturation. Throughout in vitro development, oocyte restricted transcripts were progressively degraded until the morula stage, except for MELK ; and the corresponding genes remained silent after major embryonic genome activation. Conclusion Altogether, our data emphasize the extent of post-transcriptional regulation during oocyte maturation. They do not evidence a general alteration of this phenomenon after in vitro maturation as compared to in vivo maturation, but indicate that some individual messenger RNA can be affected.