Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma

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• 作者：Qi-Kai Sun (1)
  Jian-Yu Zhu (1)
  Wei Wang (2)
  Yang Lv (1)
  Hang-Cheng Zhou (3)
  Ji-Hai Yu (1)
  Ge-Liang Xu (1) (4)
  Jin-Liang Ma (1)
  Wen Zhong (3)
  Wei-Dong Jia (1) (4)
  
• 关键词：Diagnosis ; Metastasis ; Peroxiredoxin 1 ; Prognosis ; Tumor angiogenesis
• 刊名：Medical Oncology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：31
• 期：1
• 全文大小：
• 作者单位：Qi-Kai Sun (1)
  Jian-Yu Zhu (1)
  Wei Wang (2)
  Yang Lv (1)
  Hang-Cheng Zhou (3)
  Ji-Hai Yu (1)
  Ge-Liang Xu (1) (4)
  Jin-Liang Ma (1)
  Wen Zhong (3)
  Wei-Dong Jia (1) (4)
  
  1. Department of Hepatic Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei, 230001, People? Republic of China
  2. Department of Medical Oncology, Anhui Provincial Hospital, Anhui Medical University, No. 17 Lujiang Road, Hefei, 230001, People? Republic of China
  3. Department of Pathology, Anhui Provincial Hospital, Anhui Medical University, Hefei, 230001, People? Republic of China
  4. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, No. 17 Lujiang Road, Hefei, 230001, People? Republic of China
  
• ISSN：1559-131X

文摘

Peroxiredoxin 1 (Prdx1) is a member of the peroxiredoxin family of antioxidant enzymes and implicated in cell differentiation, proliferation, and apoptosis. The aim of the present study was to determine the expression and diagnostic and prognostic significance of Prdx1 in human hepatocellular carcinoma (HCC). Prdx1 expression was examined in 76 HCC patients and 20 healthy volunteers. The relationships between Prdx1 expression and clinicopathological features were analyzed. Receiver operating characteristics analysis was used to calculate the diagnostic accuracy of serum Prdx1, serum alpha-fetoprotein (AFP), and their combination. The prognostic impact of Prdx1 on overall survival (OS) and disease-free survival (DFS) of HCC patients was investigated. Prdx1-positive rate was significantly (p?<?0.05) higher in HCC (77.1?%) than in adjacent non-tumorous liver tissues (18.4?%). Prdx1 immunoreactivity was positively correlated with tumor vascular endothelial growth factor expression and microvessel density. Prdx1 expression was significantly associated with tumor size, microvascular invasion, Edmondson grade, tumor capsula status, serum AFP, and tumor-node-metastasis stage. The combination of serum Prdx1 and AFP had a markedly higher area under the curve than serum Prdx1 alone. Positive Prdx1 expression was associated with unfavorable OS (p?=?0.004) and DFS (p?=?0.001). Multivariate analysis revealed intra-tumoral Prdx1 staining as an independent poor prognostic marker for OS (p?=?0.006) and DFS (p?=?0.002). Taken together, our data suggest that increased Prdx1 expression is associated with tumor angiogenesis and progression in HCC and serves as a promising biomarker for detection and prognosis of this malignancy.