Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish - part I: Survival and growth

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• 作者：Caroline Vignet (1)
  Karyn Le Menach (2)
  David Mazurais (3)
  Julie Lucas (1) (4)
  Prescilla Perrichon (1)
  Florane Le Bihanic (2)
  Marie-Hélène Devier (2)
  Laura Lyphout (1) (5)
  Laura Frère (5)
  Marie-Laure Bégout (5)
  José-Luis Zambonino-Infante (3)
  Hélène Budzinski (2)
  Xavier Cousin (1) (6)
  
• 关键词：Danio rerio ; Life cycle ; Polycyclic aromatic hydrocarbon ; Heavy oil ; Light crude oil ; Alkylated PAH ; Jaw ; Digestion
• 刊名：Environmental Science and Pollution Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：21
• 期：24
• 页码：13804-13817
• 全文大小：1,271 KB
• 参考文献：1. Barron MG, Heintz R, Rice SD (2004) Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish. Mar Environ Res 58:95-00 CrossRef
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  8. Cailleaud K, Forget-Leray J, Souissi S, Hilde D, LeMenach K, Budzinski H (2007) Seasonal variations of hydrophobic organic contaminant concentrations in the water-column of the Seine Estuary and their transfer to a planktonic species / Eurytemora affinis ( / Calanoida, / Copepoda). Part 1: PCBs and PAHs. Chemosphere 70:270-80 CrossRef
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  10. Danion M, Deschamps MH, Thomas-Guyon H, Bado-Nilles A, Le Floch S, Quentel C, Sire JY (2011a) Effect of an experimental oil spill on vertebral bone tissue quality in European sea bass ( / Dicentrarchus labrax L.). Ecotoxicol Environ Saf 74:1888-5 CrossRef
  11. Danion M, Le Floch S, Kanan R, Lamour F, Quentel C (2011b) Effects of in vivo chronic hydrocarbons pollution on sanitary status and immune system in sea bass (Dicentrarchus labrax L.). Aquat Toxicol 105:300-1 CrossRef
  12. Danion M, Le Floch S, Lamour F, Guyomarch J, Quentel C (2011c) Bioconcentration and immunotoxicity of an experimental oil spill in European sea bass (Dicentrarchus labrax L.). Ecotoxicol Environ Saf 74:2167-4 CrossRef
  13. Debruyn AM, Wernick BG, Stefura C, McDonald BG, Rudolph BL, Patterson L, Chapman PM (2007) In situ experimental assessment of lake whitefish development following a freshwater oil spill. Environ Sci Technol 41:6983-989 CrossRef
  14. Devier MH, Le Du-Lacoste M, Akcha F, Morin B, Peluhet L, Le Menach K, Burgeot T, Budzinski H (2013) Biliary PAH metabolites, EROD activity and DNA damage in dab ( / Limanda limanda) from Seine Estuary (France). Environ Sci Pollut Res Int 20:708-22 CrossRef
  15. Du SJ, F
• 作者单位：Caroline Vignet (1)
  Karyn Le Menach (2)
  David Mazurais (3)
  Julie Lucas (1) (4)
  Prescilla Perrichon (1)
  Florane Le Bihanic (2)
  Marie-Hélène Devier (2)
  Laura Lyphout (1) (5)
  Laura Frère (5)
  Marie-Laure Bégout (5)
  José-Luis Zambonino-Infante (3)
  Hélène Budzinski (2)
  Xavier Cousin (1) (6)
  
  1. Laboratoire d’Ecotoxicologie, Ifremer, Place Gaby Coll, BP7, 17137, L’Houmeau, France
  2. University of Bordeaux 1, EPOC, UMR CNRS 5805, 33405, Talence, France
  3. Unit of Functional Physiology of Marine Organisms, Ifremer, UMR 6539 LEMAR, 29280, Plouzané, France
  4. UMR 7266 Littoral Environnement Sociétés (LIENSs), Institut du Littoral et de l’Environnement, 2 rue Olympe de Gouges, 17000, La Rochelle, France
  5. Laboratoire Ressources Halieutiques, Ifremer, Place Gaby Coll, BP7, 17137, L’Houmeau, France
  6. INRA LPGP, Campus de Beaulieu, 35042, Rennes, France
  
• ISSN：1614-7499

文摘

The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades leading to high concentrations in sediments of contaminated areas. To evaluate the consequences of long-term chronic exposure to PAHs, zebrafish were exposed, from their first meal at 5?days post fertilisation until they became reproducing adults, to diets spiked with three PAH fractions at three environmentally relevant concentrations with the medium concentration being in the range of 4.6-.7?μg?g? for total quantified PAHs including the 16 US-EPA indicator PAHs and alkylated derivatives. The fractions used were representative of PAHs of pyrolytic (PY) origin or of two different oils of differing compositions, a heavy fuel (HO) and a light crude oil (LO). Fish growth was inhibited by all PAH fractions and the effects were sex specific: as determined with 9-month-old adults, exposure to the highest PY inhibited growth of females; exposure to the highest HO and LO inhibited growth of males; also, the highest HO dramatically reduced survival. Morphological analysis indicated a disruption of jaw growth in larvae and malformations in adults. Intestinal and pancreatic enzyme activities were abnormal in 2-month-old exposed fish. These effects may contribute to poor growth. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can promote lethal and sublethal effects which are likely to be detrimental for fish recruitment.