Tumor slice culture system to assess drug response of primary breast cancer

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• 作者：Kishan A. T. Naipal ; Nicole S. Verkaik ; Humberto Sánchez…
• 关键词：Breast cancer ; Organotypic tumor tissue slices ; Tissue culture method ; FAC chemotherapy ; Ex vivo sensitivity
• 刊名：BMC Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：2,111 KB
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• 作者单位：Kishan A. T. Naipal (1)
  Nicole S. Verkaik (1)
  Humberto Sánchez (1)
  Carolien H. M. van Deurzen (2)
  Michael A. den Bakker (3)
  Jan H.J. Hoeijmakers (1)
  Roland Kanaar (1) (4)
  Maaike P.G. Vreeswijk (5)
  Agnes Jager (6)
  Dik C. van Gent (1)
  
  1. Department of Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, PO box 2040, Rotterdam, 3000CA, The Netherlands
  2. Department of Pathology, Erasmus University Medical Center, PO box 2040, Rotterdam, 3000CA, The Netherlands
  3. Department of Pathology, Maasstad Hospital, Maasstadweg 21, Rotterdam, 3079 DZ, The Netherlands
  4. Department of Radiation Oncology, Erasmus University Medical Center, PO box 2040, Rotterdam, 3000CA, The Netherlands
  5. Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands
  6. Department of Medical Oncology, Erasmus University Medical Center, PO box 2040, Rotterdam, 3000CA, The Netherlands
  
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background The high incidence of breast cancer has sparked the development of novel targeted and personalized therapies. Personalization of cancer treatment requires reliable prediction of chemotherapy responses in individual patients. Effective selection can prevent unnecessary treatment that would mainly result in the unwanted side effects of the therapy. This selection can be facilitated by characterization of individual tumors using robust and specific functional assays, which requires development of powerful ex vivo culture systems and procedures to analyze the response to treatment.