Blood Glucagon Levels Predict the Hemoglobin A1c Response to Saxagliptin in Patients with Type 2 Diabetes Inadequately Controlled with Metformin
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- 作者：Hao Liu ; Yun Hu ; Feng-fei Li ; Bing-li Liu ; Xiao-fei Su ; Jian-hua Ma
- 关键词：Efficacy ; Glucagon ; Saxagliptin ; T2DM
- 刊名：Diabetes Therapy
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：7
- 期：4
- 页码：743-753
- 全文大小：1007KB
- 刊物主题：Internal Medicine; Diabetes; Cardiology; Endocrinology;
- 出版者：Springer Healthcare
- ISSN：1869-6961
- 卷排序：7
文摘
BackgroundDipeptidyl peptidase-4 (DPP-4) inhibitors are widely used as second-option medications when metformin fails. Variance of the glycated hemoglobin (HbA1c) response to DPP-4 inhibitions in patients with type 2 diabetes mellitus (T2DM) has been observed, but the characteristics which predict the response to DPP-4 inhibitor therapy are unclear. The aim of this study was to investigate the characteristics of α- and β-cell functions which might predict the efficacy of saxagliptin and facilitate personalization of treatment.