Bringing inorganic chemistry to life with inspiration from R. J. P. Williams

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• 作者：H. Allen O. Hill ; Peter J. Sadler
• 关键词：Irving ; Williams series ; Metalloproteins ; Vitamin B12 ; Entatic state ; The metallome ; Platinum drugs ; Essential elements
• 刊名：Journal of Biological Inorganic Chemistry
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：21
• 期：1
• 页码：5-12
• 全文大小：659 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Microbiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1327

文摘

Our appreciation of the scholarly ideas and thinking of Bob Williams is illustrated here by a few of the areas in which he inspired us. His journey to bring inorganic chemistry to life began with an early interest in analytical chemistry, rationalising the relative stabilities of metal coordination complexes (The Irving-Williams Series), and elucidating the organometallic redox chemistry of vitamin B<sub>12sub>. He (and Vallee) recognised that metal ions are in energised (entatic) states in proteins and enzymes, which themselves are dynamic structures of rods and springs. He played a key role in helping Rosenberg to pave the road toward the clinic for the anticancer drug cisplatin. He believed that evolution is not just dependent on DNA, but also on the metallome. Organisms and the environment are one system: does DNA code directly for all the essential elements of life?