Multiparametric oxygen-enhanced functional lung imaging in 3D

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• 作者：Kathrin R. F. Hemberger ; Peter M. Jakob…
• 关键词：Lung imaging ; $$T_{2}^{*}$$ T 2 ?mapping ; T 1 ; weighted imaging ; Oxygen ; enhanced ; Ultrashort echo time
• 刊名：Magnetic Resonance Materials in Physics, Biology and Medicine
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：28
• 期：3
• 页码：217-226
• 全文大小：3,996 KB
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• 作者单位：Kathrin R. F. Hemberger (1)
  Peter M. Jakob (1) (2)
  Felix A. Breuer (1)
  
  1. Research Center Magnetic-Resonance-Bavaria (MRB), Am Hubland, 97974, Wuerzburg, Germany
  2. Department of Experimental Physics 5, University of Wuerzburg, Am Hubland, 97974, Wuerzburg, Germany
  
• 刊物主题：Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1352-8661

文摘

Objective To develope a self-gated free-breathing 3D sequence allowing for simultaneous T ₁-weighted imaging and quantitative \(T_{2}^{ *}\) mapping in different breathing phases in order to assess the feasibility of oxygen-enhanced 3D functional lung imaging. Materials and methods A 3D sequence with ultrashort echo times and interleaved double readouts was implemented for oxygen-enhanced lung imaging at 1.5?T. Six healthy volunteers were examined while breathing room air as well as 100?% oxygen. Images from expiratory and inspiratory breathing phases were reconstructed and compared for the two breathing gases. Results The average \(T_{2}^{*}\) value measured for room air was 2.10?ms, with a 95?% confidence interval (CI) of 1.95-.25?ms, and the average for pure oxygen was 1.89?ms, with a 95?% CI of 1.76-.01?ms, resulting in a difference of 10.1?% (95?% CI 8.9-1.3?%). An 11.2?% increase in signal intensity (95?% CI 10.4-2.1?%) in the T ₁-weighted images was detected when subjects were breathing pure oxygen compared to room air. Furthermore, a significant change in signal intensity (26.5?%, 95?% CI 18.8-4.3?%) from expiration to inspiration was observed. Conclusions This study demonstrated the feasibility of simultaneous \(T_{2}^{*}\) mapping and T ₁-weighted 3D imaging of the lung. This method has the potential to provide information about ventilation, oxygen transfer, and lung expansion within one experiment. Future studies are needed to investigate the clinical applicability and diagnostic value of this approach in various pulmonary diseases.