Genetic susceptibility for cow's milk allergy in Dutch children: the start of the allergic march?

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• 作者：Peter Henneman ; Nicole C. M. Petrus ; Andrea Venema…
• 关键词：Epigenetics ; Food allergy ; Gender differences ; Cow’s milk allergy ; Genetic susceptibility
• 刊名：Clinical and Translational Allergy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：1
• 全文大小：1,062 KB
• 刊物主题：Allergology; Immunology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：2045-7022

文摘

Background Cow’s milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called “allergic march”. We aimed to detect genetic associations of CMA using reported single nucleotide polymorphisms (SNP) in other allergic diseases and genetic mutations within the filaggrin (FLG) gene. Both to investigate possible causes of CMA, which also suggests an “allergic march”.