Changes in hypothalamic neurotransmitter and prostanoid levels in response to NMDA, CRF, and GLP-1 stimulation

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• 作者：Fumio Kondo ; Masahiko Tachi ; Masahiko Gosho…
• 关键词：Neurotransmitters ; Prostanoids ; Hypothalamic paraventricular nucleus ; Microdialysis ; LC ; ITMSn
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：407
• 期：18
• 页码：5261-5272
• 全文大小：429 KB
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• 作者单位：Fumio Kondo (1)
  Masahiko Tachi (1)
  Masahiko Gosho (2)
  Minoru Fukayama (3)
  Kazuhiro Yoshikawa (3)
  Shoshiro Okada (1)
  
  1. Department of Pharmacology, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan
  2. Advanced Medical Research Center, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan
  3. Central Research Laboratory, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

Determination of neuroactive substances, such as neurotransmitters and prostanoids, in the extracellular space of the living brain is a very important technique in neuroscience. The hypothalamic paraventricular nucleus (PVN) is one of the most important autonomic control centers in the brain. Recently, we demonstrated that thromboxane (Tx) A2 in the PVN may play an important role in adrenomedullary outflow evoked by N-methyl-d-aspartate (NMDA), corticotrophin-releasing factor (CRF), and glucagon-like peptide-1 (GLP-1) stimulation using microdialysis sampling and liquid chromatography-ion trap tandem mass spectrometry (LC-ITMSn). In the present study, we investigated whether centrally administered NMDA, CRF, and GLP-1 can release five neurotransmitters, acetylcholine (ACh), histamine, glutamate (Glu), γ-aminobutyric acid (GABA), and serotonin (5-HT), along with six prostanoids, TxB2, prostaglandin (PG) E2, PGD2, 15-deoxy-?sup>12,14 (15d)-PGJ2, 6-keto-PGF1α, and PGF2α in rat PVN microdialysates after optimization of LC-ITMSn conditions . All stimulations increased the levels of 5-HT, TxB2, PGE2, and PGF2α (except for 5-HT stimulated with GLP-1). Only NMDA increased the levels of ACh, Glu, and GABA. Treatment with dizocilpine maleate (MK-801), a noncompetitive NMDA receptor antagonist, attenuated the NMDA-induced increase in the levels of neuroactive substances except for Glu. This is the first study to use LC-ITMSn to analyze neurotransmitters and prostanoids in the same microdialysates from rat PVN.