Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

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• 作者：Golo Kronenberg ; Valentina Mosienko…
• 关键词：BDNF ; SERT ; TPH2 ; Serotonin ; Depression ; Antidepressant
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：266
• 期：3
• 页码：281-284
• 全文大小：559 KB
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• 作者单位：Golo Kronenberg (1)
  Valentina Mosienko (2) (4)
  Karen Gertz (3)
  Natalia Alenina (2)
  Rainer Hellweg (1)
  Friederike Klempin (2)
  
  1. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - University Medicine Berlin, Berlin, Germany
  2. Research Team ‘Cardiovascular Hormones and Peptides’, Max-Delbruck-Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany
  4. School of Physiology and Pharmacology, University of Bristol, Bristol, UK
  3. Department of Neurology, Charité - University Medicine Berlin, Berlin, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Psychiatry
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8491

文摘

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 −/−) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT−/−) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 −/− mice, whereas no significant changes were observed in SERT−/− mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 −/− but not of SERT−/− mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.