Single-step assembly of polymer-lipid hybrid nanoparticles for mitomycin C delivery

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• 作者：Yunfeng Yi (1)
  Yang Li (2) (3)
  Hongjie Wu (4)
  Mengmeng Jia (2)
  Xiangrui Yang (2)
  Heng Wei (2)
  Jinyan Lin (2)
  Shichao Wu (2) (3)
  Yu Huang (2)
  Zhenqing Hou (2)
  Liya Xie (5)
  
  1. The Affiliated Southeast Hospital of Xiamen University ; Xiamen University ; Zhangzhou ; 363000 ; China
  2. Department of Biomaterials ; College of Materials ; Xiamen University ; Xiamen ; 361005 ; China
  3. Department of Chemistry ; College of Chemistry and Chemical Engineering ; Xiamen University ; Xiamen ; 361005 ; China
  4. Department of Pharmacy ; School of Pharmaceutical Science ; Xiamen University ; Xiamen ; 361005 ; China
  5. The First Affiliated Hospital of Xiamen University ; Xiamen ; 361003 ; China
  
• 关键词：Cancer chemoprevention ; Controlled release ; Drug delivery systems ; Phospholipids ; Self ; assembly
• 刊名：Nanoscale Research Letters
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：2,536 KB
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• 刊物主题：Nanotechnology; Nanotechnology and Microengineering; Nanoscale Science and Technology; Nanochemistry; Molecular Medicine;
• 出版者：Springer US
• ISSN：1556-276X

文摘

Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 to 101) and biodegradable polylactic acid (PLA) polymers for intravenous MMC delivery. The advantage of the MMC-SPC complex on the polymer-lipid hybrid NPs was that MMC-SPC was used as a structural element to offer the integrity of the hybrid NPs, served as a drug preparation to increase the effectiveness and safety and control the release of MMC, and acted as an emulsifier to facilitate and stabilize the formation. Compared to the PLA NPs/MMC, the PLA NPs/MMC-SPC showed a significant accumulation of MMC in the nuclei as the action site of MMC. The PLA NPs/MMC-SPC also exhibited a significantly higher anticancer effect compared to the PLA NPs/MMC or free MMC injection in vitro and in vivo. These results suggested that the MMC-loaded polymer-lipid hybrid NPs might be useful and efficient drug delivery systems for widening the therapeutic window of MMC and bringing the clinical use of MMC one step closer to reality.