Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria

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• 作者：Talleh Almelli (19) (20)
  Nicaise T Ndam (19) (20)
  Sem Ezimegnon (21)
  Maroufou J Alao (22)
  Charles Ahouansou (21)
  Gratien Sagbo (23)
  Annick Amoussou (24)
  Philippe Deloron (19) (20)
  Rachida Tahar (19) (20)
  
  19. Institut de Recherche pour le D茅veloppement (IRD) ; UMR 216 M猫re et Enfant Face aux Infections Tropicales ; 4 ; avenue de l鈥橭bservatoire ; Paris ; 75270 ; France
  20. PRES Sorbonne Paris Cit茅 ; Facult茅 de Pharmacie ; Universit茅 Paris Descartes ; Paris ; France
  21. Centre d鈥橢tude et de recherche sur le Paludisme Associ茅 脿 la Grossesse et l鈥橢nfance (CERPAGE) ; Cotonou ; B茅nin
  22. D茅partement de p茅diatrie ; H么pital M猫re-enfant de la lagune (HOMEL) ; Cotonou ; B茅nin
  23. Service de p茅diatrie ; Centre National Hospitalo-Universitaire (CNHU) ; Cotonou ; B茅nin
  24. Service de p茅diatrie ; H么pital de zone de Suru-L茅r茅 ; Cotonou ; B茅nin
  
• 关键词：Plasmodium falciparum ; Cerebral malaria ; Uncomplicated malaria ; Var genes ; Domain cassette ; Transcript abundance ; Cytoadherence ; CD36 ; ICAM ; 1 ; CSPG ; CSA
• 刊名：Malaria Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：619 KB
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• 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
• 出版者：BioMed Central
• ISSN：1475-2875

文摘

Background Cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral malaria (CM). This biological process is thought to be mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP-1) and human receptors such as CD36 and ICAM-1. The relationship between the expression of PfEMP-1 variants and cytoadherence phenotype in the pathology of malaria is not well established. Methods Cytoadherence phenotypes of IEs to CD36, ICAM-1, CSPG and the transcription patterns of A, B, var2csa, var3, var gene groups and domain cassettes DC8 and DC13 were assessed in parasites from children with CM and uncomplicated malaria (UM) to determine if cytoadherence is related to a specific transcription profile of pfemp-1 variants. Results Parasites from CM patients bind significantly more to CD36 than those from UM patients, but no difference was observed in their binding ability to ICAM-1 and CSPG. CM isolates highly transcribed groups A, B, var2csa, var3, DC8 and DC13 compared to UM parasites. The high transcription levels of var genes belonging to group B positively correlated with increased binding level to CD36. Conclusion CM isolates bind significantly more to CD36 than to ICAM-1, which was correlated with high transcription level of group B var genes, supporting their implication in malaria pathogenesis.