Optimization of lipase-catalyzed synthesis of caffeic acid phenethyl ester in ionic liquids by response surface methodology
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- 作者：Sung Ho Ha (1)
Tran Van Anh (2)
Yoon-Mo Koo (2) - 关键词：Ionic liquids ; Caffeic acid phenethyl ester ; Lipase ; Optimization ; Response surface methodology ; Central composite rotatable design
- 刊名：Bioprocess and Biosystems Engineering
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：36
- 期：6
- 页码：799-807
- 全文大小：420KB
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Tran Van Anh (2)
Yoon-Mo Koo (2)
1. Department of Chemical Engineering and Nano-Bio Technology, Hannam University, Daejeon, 305-811, Korea
2. Department of Biological Engineering, Inha University, Incheon, 402-751, Korea - ISSN：1615-7605
文摘
Lipase-catalyzed caffeic acid phenethyl ester (CAPE) synthesis in ionic liquid, 1-ethyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([Emim][Tf2N]), was investigated in this study. The effects of several reaction conditions, including reaction time, reaction temperature, substrate molar ratio of phenethyl alcohol to caffeic acid (CA), and weight ratio of enzyme to CA, on CAPE yield were examined. In a single parameter study, the highest CAPE yield in [Emim][Tf2N] was obtained at 70?°C with a substrate molar ratio of 30:1 and weight ratio of enzyme to CA of 15:1. Based on these results, response surface methodology (RSM) with a 3-level-4-factor central composite rotatable design (CCRD) was adopted to evaluate enzymatic synthesis of CAPE in [Emim][Tf2N]. The four major factors were reaction time (36-0?h), reaction temperature (65-5?°C), substrate molar ratio of phenethyl alcohol to CA (20:1-0:1), and weight ratio of enzyme to CA (10:1-0:1). A quadratic equation model was used to analyze the experimental data at a 95?% confidence level (p?<?0.05). A maximum conversion yield of 99.8?% was obtained under the optimized reaction conditions [60?h, 73.7?°C, substrate molar ratio of phenethyl alcohol to CA (27.1:1), and weight ratio of enzyme to CA (17.8:1)] established by our statistical method, whereas the experimental conversion yield was 96.6?±?2?%.