Synthesis and evaluation of antimicrobial and anthelmintic activity of novel fluorinated 7-ethyl-10H-phenothiazines, their sulphones and ribofuranosides

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• 作者：NAVEEN GAUTAM (1)
  ABHILASHA YADAV (2)
  NISHIDHA KHANDELWAL (2)
  D C GAUTAM (2)
  
• 关键词：10H ; Phenothiazines ; Smiles rearrangement ; sulphones ; ribofuranosides ; antimicrobial activity ; anthelmintic activity
• 刊名：Journal of Chemical Sciences
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：126
• 期：1
• 页码：197-204
• 全文大小：315 KB
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• 作者单位：NAVEEN GAUTAM (1)
  ABHILASHA YADAV (2)
  NISHIDHA KHANDELWAL (2)
  D C GAUTAM (2)
  
  1. LBS Government PG College, Kotputli, Jaipur, 303 108, India
  2. Department of Chemistry, University of Rajasthan, JLN Marg, Jaipur, 302 004, India
  
• ISSN：0973-7103

文摘

A series of novel fluorinated 10H-phenothiazines were synthesized via Smiles rearrangement. 10H-phenothiazines on refluxing with 30% hydrogen peroxide in glacial acetic acid gave 10H-phenothiazines-5, 5-dioxides (sulphones). These synthesized 10H-phenothiazines were then used as base to prepare ribofuranosides by treating them with sugar ( β-D-ribofuranosyl- 1-acetate-2, 3, 5-tribenzoate). The synthesized compounds were screened for antimicrobial activity and anthelmintic activity. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis. Figure 10H-phenothiazines were prepared by Smiles rearrangement. These prepared phenothiazines were used as a base to prepare ribofuranosides by treating with β-D-ribofuranose-1-acetate-2, 3, 5-tribenzoate. The structures of the synthesized compounds have been established by elemental analysis and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial and anthelmintic activity.