The Case for Absolute Ligand Discrimination: Modeling Information Processing and Decision by Immune T Cells

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• 作者：Paul François ; Grégoire Altan-Bonnet
• 关键词：T Cell ; Immune decision ; Kinetic proofreading ; Adaptive sorting ; Phenotypic variability ; Feedback
• 刊名：Journal of Statistical Physics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：162
• 期：5
• 页码：1130-1152
• 全文大小：1,689 KB
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Statistical Physics
  Mathematical and Computational Physics
  Physical Chemistry
  Quantum Physics
  
• 出版者：Springer Netherlands
• ISSN：1572-9613

文摘

Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name “absolute discrimination”. An example of absolute discrimination is recognition of not-self by immune T Cells. We show how the problem of absolute discrimination can be solved by a process called “adaptive sorting”. We review several implementations of adaptive sorting, as well as its generic properties such as antagonism. We show how kinetic proofreading with negative feedback implement an approximate version of adaptive sorting in the immune context. Finally, we revisit the decision problem at the cell population level, showing how phenotypic variability and feedbacks between population and single cells are crucial for proper decision.