The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection
详细信息 查看全文
- 作者：David A. Price ; U.-C. Meier ; Paul Klenerman ; Marco A. Purbhoo ; Rodney E. Phillips and A. K. Sewell
- 关键词：Key words Human immunodeficiency virus ; 1 ; Cytotoxic T lymphocyte ; Altered peptide ligand
- 刊名：Journal of Molecular Medicine
- 出版年：1998
- 出版时间：August 1998
- 年：1998
- 卷：76
- 期：10
- 页码：699-708
- 全文大小：236 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Molecular Medicine
Internal Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1440
文摘
The propensity of HIV-1 for genetic variation, a consequence of error-prone reverse transcription combined with high rates of replication, is thought to contribute to the establishment of persistent infection in the host despite the presence of a vigorous antiviral immune response. Protective immunity to viruses is mediated primarily by cytotoxic T lymphocytes, which recognize viral peptides of 8–11 amino acids bound to major histocompatibility complex class I molecules on the surface of infected cells. In this review we examine the mechanisms by which mutation within peptide antigen-encoding regions of the viral genome enables HIV-1 to evade recognition by virus-specific cytotoxic T lymphocytes. The discussion is relevant to other genetically unstable viruses and more generally to intracellular pathogens of variable antigenicity.