Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

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• 作者：Ephraim P. Lansky ; Wenguo Jiang ; Huanbiao Mo ; Lou Bravo ; Paul Froom ; Weiping Yu ; Neil M. Harris ; Ishak Neeman and Moray J. Campbell
• 关键词：botanical ; chaos ; chemoprevention ; complex drug ; complexity ; drug design ; drug discovery ; natural product
• 刊名：Investigational New Drugs
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：23
• 期：1
• 页码：11-20
• 全文大小：317 KB

文摘

We investigated whether dissimilar biochemical fractions originating in anatomically discrete sections of the pomegranate (Punica granatum) fruit might act synergistically against proliferation, metastatic potential, and phosholipase A2 (PLA2) expression of human prostate cancer cells in vitro. Proliferation of DU 145 human prostate cancer cells was measured following treatment with a range of therapeutically active doses of fermented pomegranate juice polyphenols (W) and sub-therapeutic doses of either pomegranate pericarp (peel) polyphenols (P) or pomegranate seed oil (Oil). Invasion across Matrigel by PC-3 human prostate cancer cells was measured following treatment with combinations of W, P and Oil such that the total gross weight of pomegranate extract was held constant. Expression of PLA2, associated with invasive potential, was measured in the PC-3 cells after treatment with the same dosage combinations as per invasion. Supra-additive, complementary and synergistic effects were proven in all models by the Kruskal-Wallis non-parametric H test at p p p