Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells

详细信息    查看全文

• 作者：Laura Marise de Freitas ; Rodolfo Bortolozo Serafim ; Juliana Ferreira de Sousa…
• 关键词：Photodynamic therapy ; Methylene blue ; Photogem ; Cisplatin ; Combined therapy ; Caspase ; independent cell death
• 刊名：BMC Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：1304KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2407
• 卷排序：17

文摘

BackgroundPhotodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxic photosensitizing agent to the patient with subsequent localized exposure to a light source of a specific wavelength, resulting in a cytotoxic response to oxidative damage. The present study intended to evaluate in vitro the type of induced death and the genotoxic and mutagenic effects of PDT alone and associated with cisplatin.