Effect of Carbonyl Inhibitors and Their H2O2 Detoxification on Lactic Acid Fermentation

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• 作者：Jing Li ; Caiqing Zhu ; Maobing Tu ; Pingping Han…
• 关键词：Lactic acid fermentation ; H2O2 detoxification ; Carbonyl compounds ; Inhibition ; Lactobacillus delbrueckii
• 刊名：Applied Biochemistry and Biotechnology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：175
• 期：8
• 页码：3657-3672
• 全文大小：493 KB
• 参考文献：1. Boguta, A. M., Bringel, F., Martinussen, J. and Jensen, P. R. (2014). Screening of lactic acid bacteria for their potential as microbial cell factories for bioconversion of lignocellulosic feedstocks. / Microb Cell Fact, 13
  2. Chen, SF, Mowery, RA, Castleberry, VA, Walsum, GP, Chambliss, CK (2006) High-performance liquid chromatography method for simultaneous determination of aliphatic acid, aromatic acid and neutral degradation products in biomass pretreatment hydrolysates. Journal of Chromatography A 1104: pp. 54-61 CrossRef
  3. Nichols, NN, Sharma, LN, Mowery, RA, Chambliss, CK, Walsum, GP, Dien, BS, Iten, LB (2008) Fungal metabolism of fermentation inhibitors present in corn stover dilute acid hydrolysate. Enzyme and Microbial Technology 42: pp. 624-630 CrossRef
  4. Olsson, L, HahnHagerdal, B (1996) Fermentation of lignocellulosic hydrolysates for ethanol production. Enzyme and Microbial Technology 18: pp. 312-331 CrossRef
  5. Cao, DX, Tu, MB, Xie, R, Li, J, Wu, YN, Adhikari, S (2014) Inhibitory activity of carbonyl compounds on alcoholic fermentation by saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry 62: pp. 918-926 CrossRef
  6. Franden, M. A., Pilath, H. M., Mohagheghi, A., Pienkos, P. T., and Zhang, M. (2013). Inhibition of growth of Zymomonas mobilis by model compounds found in lignocellulosic hydrolysates. / Biotechnol Biofuels, 6
  7. Zaldivar, J, Ingram, LO (1999) Effect of organic acids on the growth and fermentation of ethanologenic Escherichia coli LY01. Biotechnology and Bioengineering 66: pp. 203-210 CrossRef
  8. Zaldivar, J, Martinez, A, Ingram, LO (1999) Effect of selected aldehydes on the growth and fermentation of ethanologenic Escherichia coli. Biotechnology and Bioengineering 65: pp. 24-33 CrossRef
  9. Zaldivar, J, Martinez, A, Ingram, LO (2000) Effect of alcohol compounds found in hemicellulose hydrolysate on the growth and fermentation of ethanologenic Escherichia coli. Biotechnology and Bioengineering 68: pp. 524-530 CrossRef
  10. Larsson, S, Quintana-Sainz, A, Reimann, A, Nilvebrant, NO, Jonsson, LJ (2000) Influence of lignocellulose-derived aromatic compounds on oxygen-limited growth and ethanolic fermentation by Saccharomyces cerevisiae. Applied Biochemistry and Biotechnology 84-: pp. 617-632 CrossRef
  11. Chan, K, O’Brien, PJ (2008) Structure-activity relationships for hepatocyte toxicity and electrophilic reactivity of alpha, beta-unsaturated esters, acrylates and methacrylates. Journal of Applied Toxicology 28: pp. 1004-1015 CrossRef
  12. Schultz, TW, Yarbrough, JW, Johnson, EL (2005) Structure-activity relationships for reactivity of carbonyl-containing compounds with glutathione. Sar and Qsar in Environmental Research 16: pp. 313-322 CrossRef
  13. Schwobel, JAH, Wondrousch, D, Koleva, YK, Madden, JC, Cronin, MTD, Schuurmann, G (2010) Prediction of Michael-type acceptor reactivity toward glutathione. Chemical Research in Toxicology 23: pp. 1576-1585 CrossRef
  14. Schwobel, JAH, Koleva, YK, Enoch, SJ, Bajot, F, Hewitt, M, Madden, JC, Roberts, DW, Schutz, TW, Cronin, MTD (2011) Measurement and estimation of electrophilic reactivity for predictive toxicology. Chemistry Review 111: pp. 2562-2596 CrossRef
  15. Zhang, DX, Ong, YL, Li, Z, Wu, JC (2013) Biological detoxification of furfural and 5-hydroxyl methyl furfural in hydrolysate of oil palm empty fruit bunch b
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Biochemistry
  
• 出版者：Humana Press Inc.
• ISSN：1559-0291

文摘

Biomass degradation compounds significantly inhibit biochemical conversion of biomass prehydrolysates to biofuels and chemicals, such as lactic acid. To characterize the structure-activity relationship of carbonyl inhibition on lactic acid fermentation, we examined effects of eight carbonyl compounds (furfural, 5-hydroxymethyl furfural, vanillin, syringaldehyde, 4-hydroxybenzaldehyde, phthalaldehyde, benzoic acid, and pyrogallol aldehyde) and creosol on lactic acid production by Lactobacillus delbrueckii. Pyrogallol aldehyde reduced the cell growth rate by 35?% at 1.0?mM and inhibited lactic acid production completely at 2.0?mM. By correlating the molecular descriptors to the inhibition constants in lactic acid fermentation, we found a good relationship between the hydrophobicity (Log P) of aldehydes and their inhibition constants in fermentation. The inhibitory effect of carbonyl inhibitors appeared to correlate with their thiol reactivity as well. In addition, we found that H2O2 detoxified pyrogallol aldehyde and phthalaldehyde inhibitory activity. H2O2 detoxification was applied to real biomass prehydrolysates in lactic acid fermentation.