Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence
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- 作者：Helen P. Pizzo ; Robert B. Ettenger ; David W. Gjertson…
- 关键词：Compliance ; Immunosuppression ; Drug levels ; Calcineurin inhibitor ; Mammalian target of rapamycin inhibitor
- 刊名：Pediatric Nephrology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：31
- 期：12
- 页码：2345-2352
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Pediatrics; Nephrology; Urology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-198X
- 卷排序：31
文摘
BackgroundImmunosuppression medication nonadherence has been associated with donor-specific antibodies and treatment-refractory rejection. Drug-level monitoring is a practical direct marker for nonadherence, as variations indicate erratic ingestion of medication. We previously reported that high variability in tacrolimus trough levels determined by the percent coefficient of variation (CV %) and standard deviation (SD) were associated with biopsy-proven rejection. We hypothesized that the CV % and SD in patients on a sirolimus/low-dose tacrolimus regimen may associate with self-reported medication nonadherence, rejection and donor-specific antibodies.