The decidua—the maternal bed embracing the embryo—maintains the pregnancy

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• 作者：Mayumi Mori ; Agnes Bogdan ; Timea Balassa ; Timea Csabai…
• 关键词：Decidua ; Endometrium ; Pregnancy ; Infertility ; Preeclampsia ; Vascular remodeling
• 刊名：Springer Seminars in Immunopathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：38
• 期：6
• 页码：635-649
• 全文大小：1,885 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1863-2300
• 卷排序：38

文摘

The decidua has been known as maternal uterine tissue, which plays essential roles in protecting the embryo from being attacked by maternal immune cells and provides nutritional support for the developing embryo prior to placenta formation. However, there are questions that still remain to be answered: (1) How does the decidua supply nutrition and provide a physical scaffold for the growing embryo, before placental vascular connection is established? (2) How is the balance between preventing an anti-embryo immune response and protecting both embryo and mother from infections established? To understand basic personas in decidual tissues, we review the structure of the decidua composed of terminally differentiated uterine stromal cells, blood vessels, and a number of repertoire of uterine local immune cells, including the well-known uterine natural killer (uNK) cells and recently discovered innate lymphoid cells (ILCs). Decidual macrophages and uterine dendritic cells (DCs) are supposed to modulate adaptive immunity via balancing cytokines and promoting generation of regulatory T (T_reg) cells. During decidualization, vascular and tissue remodeling in the uterus provide nutritional and physical support for the developing embryo. Secretion of various cytokines and chemokines from both the embryo and the decidual cells activates multiple signaling network between the mother and the embryo upon implantation. Defects in the decidual development during early pregnancy result in loss of pregnancy or complications in later gestational stage.