Sensitive LC-MS/MS Method for the Determination of Ramipril in Human Plasma: Application to a Bioequivalence Study in Indian Volunteers
详细信息 查看全文
- 作者：Arabinda Saha ; Poonam Vats ; Sanjay Jagannath Gurule…
- 关键词：Back conversion ; Bioequivalence study ; Liquid chromatography ; mass spectrometry ; Ramipril ; Ramipril acyl glucuronide ; Phase II metabolite
- 刊名：Journal of Pharmaceutical Innovation
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：12
- 期：1
- 页码：90-104
- 全文大小：
- 刊物主题：Pharmacology/Toxicology; Industrial and Production Engineering; Biotechnology; Biochemical Engineering;
- 出版者：Springer US
- ISSN：1939-8042
- 卷排序：12
文摘
PurposeSensitive and selective analytical method is required for the estimation of ramipril in human plasma as ramipril has been reported to have high intra-subject variability and phase II inactive metabolite (ramipril acyl glucuronide) back-converted to ramipril in an in vitro system. If this back conversion is not restricted, it could lead to pseudo estimation of ramipril in human plasma.