Diagnostic Issues in a Case of Hodgkin Lymphoma with Castleman Like Features

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• 作者：Suganya K. Reddy (1)
  Jinkala Sree Rekha (1)
  Sajini Elizabeth Jacob (1)
  Debdatta Basu (1)
  
  1. Department of Pathology ; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) ; Puducherry ; 605006 ; India
  
• 关键词：Castleman disease ; Hodgkin lymphoma ; Immunohistochemistry
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：30
• 期：1-supp
• 页码：386-389
• 全文大小：914 KB
• 参考文献：1. Haque, S, Kirk, R (2009) Three patients with both Hodgkin鈥檚 lymphoma and Castleman鈥檚 disease: clinicopathologic correlations and lack of association with HHV-8. Indian J Med Paediatr Oncol 30: pp. 76-79 CrossRef
  2. Zarate-Osorno, A, Medeiros, LJ, Danon, AD, Neiman, RS (1994) Hodgkin鈥檚 disease with coexistent Castleman-like histologic features. A report of three cases. Arch Pathol Lab Med 118: pp. 270-274
  3. Ioachim HL, Medeiros LJ (eds) (2008) Castleman lymphadenopathy. In: Ioachim鈥檚 lymph node pathology. Lippincott Williams & Wilkins, Philadelphia
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  8. Larroche, C, Cacoub, P, Soulier, J, Oksenhendler, E, Clauvel, J-P, Piette, J-C, Raphel, M (2002) Castleman disease and lymphoma: report of eight cases in HIV negative patients and literature review. Am J Hematol 69: pp. 119-126 CrossRef
  
• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449

文摘

Castleman disease (CD) is a benign heterogenous lymphoproliferative disorder presenting with varied clinical manifestations. Histomorphologically, two distinct variants are known, hyaline vascular type and plasma cell type. CD is reported to be associated with lymphomas. Though Non Hodgkin lymphoma is more commonly associated with CD, its association with Hodgkin lymphoma (HL) is also well known and documented. Many a times, CD obscures or masks the underlying lymphomas thus delaying the diagnosis. There are also reports of HL showing Castleman like features. We report a case of HL with Castleman like features which posed diagnostic difficulty owing to the fragmented nature and tiny size of the initial lymph node biopsy. Striking peripheral blood rouleaux formation which was seen in our case along with bone marrow plasmacytosis has not been described in the previously diagnosed cases.