A case of ‘fat-free-pleomorphic lipoma occurring in the upper back and axilla simultaneously

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• 作者：Liang Wang (1) (2)
  Yang Liu (1) (2)
  Di Zhang (1) (2)
  Yong Zhang (1) (2)
  Na Tang (1) (2)
  En-Hua Wang (1) (2)
  
• 关键词：Spindle cell lipoma ; Pleomorphic lipoma ; Atypical lipomatous tumor ; Myxoid liposarcoma ; Pleomorphic hyalinizing angiectatic tumor
• 刊名：World Journal of Surgical Oncology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：558KB
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• 作者单位：Liang Wang (1) (2)
  Yang Liu (1) (2)
  Di Zhang (1) (2)
  Yong Zhang (1) (2)
  Na Tang (1) (2)
  En-Hua Wang (1) (2)
  
  1. Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, North 2nd Road, 92#, Shenyang, 110001, China
  2. Institute of pathology and pathophysiology, China Medical University, North 2nd Road, 92#, Shenyang, 110001, China
  

文摘

Pleomorphic lipoma is a rare neoplasm that predominantly occurs in the dermis or subcutis of the posterior neck, upper back, and shoulders. Although pleomorphic lipoma is a benign tumor, it may contain atypical cells. As a variant of spindle cell lipoma, pleomorphic lipoma clinically presents as a slow-growing and well-circumscribed subcutaneous mass. Rarely, some patients have multiple lesions. Histologically, pleomorphic lipoma is composed of mature fat, bland spindle-shaped mesenchymal cells, and coarse ‘rope-like-collagen bands. In addition, lipoma contains multinucleated floret-like giant cells. Although spindle cell lipoma/pleomorphic lipoma with little fat was seen in the original series described by Enzinger and Harvey, cases with little to no fat remain diagnostically challenging. Herein, we report a case of ‘fat-free-pleomorphic lipoma occurring in the upper back and axilla simultaneously. Although the lipoma was typically composed of bland spindle-shaped cells, rope-like collagen, scattered floret-like giant cells, and striking stromal myxoid change in the background, mature fat was absent. Immunohistochemical analyses showed positive staining for CD34, vimentin, and Bcl-2, and negative staining for S100, confirming the diagnosis of pleomorphic lipoma.