Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine

详细信息    查看全文

• 作者：Artitaya Thiengsusuk (1)
  Wanna Chaijaroenkul (1)
  Kesara Na-Bangchang (1)
  
• 刊名：Parasitology Research
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：112
• 期：4
• 页码：1475-1481
• 全文大小：148KB
• 参考文献：1. Azebaze AG, Meyer M, Valentin A, Nguemfo EL, Fomum ZT, Nkengfack AE (2006) Prenylated xanthone derivatives with antiplasmodial activity from / Allanblackia monticola STANER L.C. Chem Pharm Bull 54(1):111-13 CrossRef
  2. Bennett TN, Paguio M, Gligorijevic B, Seudieu C, Kosar AD, Davidson E, Roepe PD (2004) Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy. Antimicrob Agents Chemother 48:1807-810 CrossRef
  3. Chu D, Miles H, Toney D, Ngyuen C, Marciano-Cabral F (1998) Amebicidal activity of plant extracts from Southeast Asia on / Acanthamoeba spp. Parasitol Res 84(9):746-52 CrossRef
  4. Connolly JD, Deans R, Haque ME (1995) Constituents of / Piper chaba. Fitoterapia 66(2):188
  5. Durga R, Sridhar P, Polasa H (1990) Effects of plumbagin on antibiotic resistance in bacteria. Indian J Med Res 91:18-0
  6. Firestone GL, Sundar SN (2009) Anticancer activities of artemisinin and its bioactive derivatives. Expert Rev Mol Med 11:e32 CrossRef
  7. Lambros C, Vanderberg JP (1979) Synchronization of / Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65(3):418-20 CrossRef
  8. Likhitwitayawuid K, Chanmahasathien W, Ruangrungsi N, Krungkrai J (1998a) Xanthones with antimalarial activity from / Garcinia dulcis. Planta Med 64(3):281-82 CrossRef
  9. Likhitwitayawuid K, Kaewamatawong R, Ruangrungsi N, Krungkrai J (1998b) Antimalarial naphthoquinones from / Nepenthes thorelii. Plant Med 64(3):237-41 CrossRef
  10. Likhitwitayawuid K, Sawasdee K, Kirtikara K (2002) Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from / Dracaena loureiri. Plant Med 68(9):841-43 CrossRef
  11. Lin LC, Yang LL, Chou CJ (2003) Cytotoxic naphthoquinones and plumbagic acid glucosides from / Plumbago zeylanica. Phytochemistry 62(4):619-22 CrossRef
  12. Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K (2003) Hepatoprotective effect of myristicin from nutmeg ( / Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury. J Agric Food Chem 51(6):1560-565 CrossRef
  13. Na-Bangchang K, Congpuong K (2007) Current malaria status and distribution of drug resistance in East and Southeast Asia with special focus to Thailand. Tohoku J Exp Med 211:99-13 CrossRef
  14. Na-Bangchang K, Ruengweerayut R, Muhamad P, Chaijaroenkul W (2010) Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai–Myanmar border. Mal J 8:273-80
  15. Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM (2008) Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 359(24):2619-620 CrossRef
  16. Parimala R, Sachdanandam P (1993) Effect of plumbagin on some glucose metabolizing enzymes studied in rats in experimental hepatoma. Mol Cell Biochem 125(1):59-3 CrossRef
  17. Rasoanaivo P, Deharo E, Urverg SR, Frappier F (2004) Guidelines for the nonclinical evaluation of the efficacy of traditional antimalarials. In: Willcox M, Rasoanaivo P, Bodeker G (eds) Traditional medicinal plants and malaria. CRC Press, Boca Raton, Chapter 16
  18. Riscoe M, Kelly JX, Winter R (2005) Xanthones as antimalarial agents: discovery, mode of action, and optimization. Curr Med Chem 12(21):2539-549 CrossRef
  19. Saekoo J, Graidist P, Leeanansaksiri W, Dechsukum C, Itharat A (2010) Dioscorealide B from the traditional Thai medicine Hua-Khao-Yen induces apoptosis in MCF-7 human breast cancer cells via modulation of Bax, Bak and Bcl-2 protein expression. Nat Prod Commun 5(12):1921-926
  20. Schwikkard S, van Heerden F (2002) Antimalarial activity of plant metabolites. Nat Prod Rep 19(6):675-92 CrossRef
  21. Sudhanshu S, Neerja P, Jain DC, Bhakuni RS (2003) Antimalarial agents from plant sources. Curr Sci 85(9):1314-329
  22. Sugie S, Okamoto K, Rahman KM, Tanaka T, Kawai K, Yamahara J, Mori H (1998) Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett 127(1-):177-83 CrossRef
  23. Trager W, Jensen JB (1976) Human malaria culture parasite in continuous culture. Science 193:673-75 CrossRef
  24. Wang YC, Huang TL (2005) High-performance liquid chromatography for quantification of plumbagin, an anti- / Helicobacter pylori compound of / Plumbago zeylanica L. J Chromatogr A 1094(1-):99-04
  25. World Health Organisation (2006) Guidelines for the treatment of malaria. Geneva, WHO, HTM/MAL/110
  
• 作者单位：Artitaya Thiengsusuk (1)
  Wanna Chaijaroenkul (1)
  Kesara Na-Bangchang (1)
  
  1. Thailand Center of Excellence in Drug Discovery and Development (TCEDDD), Thammasat University, Rangsit Campus, Rangsit, Pathumtani, 12121, Thailand
  
• ISSN：1432-1955

文摘

Malaria is one of the world's leading killer infectious diseases with high incidence and morbidity. The problem of multidrug-resistant Plasmodium falciparum has been aggravating particularly in Southeast Asia. Therefore, development of new potential antimalarial drugs is urgently required. The present study aimed to investigate antimalarial activities of a total of 27 medicinal plants and 5 herbal formulations used in Thai traditional medicine against chloroquine-resistant (K1) and chloroquine-sensitive (3D7) P. falciparum clones. Antimalarial activity of the ethanolic extracts of all plants/herbal formulations against K1 and 3D7 P. falciparum clones was assessed using SYBR Green I-based assay. All plants were initially screened at the concentration of 50?μg/ml to select the candidate plants that inhibited malaria growth by ?0?%. Each candidate plant was further assessed for the IC50 value (concentration that inhibits malaria growth by 50?%) to select the potential plants. Selectivity index (SI) of each extract was determined from the IC50 ratio obtained from human renal epithelial cell and K1 or 3D7 P. falciparum clone. The ethanolic extracts from 19 medicinal plants/herbal formulation exhibited promising activity against both K1 and 3D7 clones of P. falciparum with survival of less than 50?% at the concentration of 50?μg/ml. Among these, the extracts from the eight medicinal plants (Plumbago indica Linn., Garcinia mangostana Linn., Dracaena loureiri Gagnep., Dioscorea membranacea Pierre., Artemisia annua Linn., Piper chaba Hunt., Myristica fragrans Houtt., Kaempferia galanga Linn.) and two herbal formulations (Benjakul Formulation 1 and Pra-Sa-Prao-Yhai Formulation) showed potent antimalarial activity with median range IC50 values of less than 10?μg/ml against K1 or 3D7 P. falciparum clone or both. All except G. mangostana Linn. and A. annua Linn. showed high selective antimalarial activity against both clones with SI-gt;-0. Further studies on antimalarial activities in an animal model including molecular mechanisms of action of the isolated active moieties are required.