Is the role of rhinoviruses as causative agents of pediatric community-acquired pneumonia over-estimated?

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• 作者：Tatyana V. Spichak ; Svetlana B. Yatsyshina…
• 关键词：Community ; acquired pneumonia ; Respiratory syncytial virus ; Adenoviruses ; Rhinoviruses ; Human bocavirus ; Child
• 刊名：European Journal of Pediatrics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：175
• 期：12
• 页码：1951-1958
• 全文大小：
• 刊物主题：Pediatrics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1076
• 卷排序：175

文摘

The role that rhinoviruses, enteroviruses, parainfluenza viruses, coronaviruses and human bocavirus play in pediatric pneumonia is insufficiently studied. We used polymerase chain reaction (PCR) to study 9 virus groups, including 16 different viruses or viral strains, in 56 ambulatory children with radiologically confirmed community-acquired pneumonia (CAP). The same tests were carried out on 474 apparently healthy control children of the same age and sex. The mean age of children with CAP was 6.5 years (SD 4.2). Respiratory syncytial virus (RSV) was found in 19.6 % of 56 cases and in 2.1 % of 474 controls. Adenoviruses were present in 12.5 % of cases (0.2 % controls) and metapneumovirus and influenza A virus each in 10.7 % of cases (0.2 % controls). Interestingly, rhinoviruses were less common in cases (10.7 %) than in controls (22.4 %): odds ratio 0.36 (95%CI) 0.15–0.87) in conditional logistic regression including 56 cases and 280 controls matched for age, sex and sampling month. The prevalence of parainfluenza viruses, enteroviruses, coronaviruses and human bocavirus were similar in both groups.