Risk factors for young-onset colorectal cancer

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• 作者：Valentina Rosato (1) (2)
  Cristina Bosetti (1)
  Fabio Levi (3)
  Jerry Polesel (4)
  Antonella Zucchetto (2) (4)
  Eva Negri (1)
  Carlo La Vecchia (1) (2)
  
• 关键词：Colorectal cancer ; Family history ; Foods ; Nutrients ; Risk factors ; Young
• 刊名：Cancer Causes and Control
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：24
• 期：2
• 页码：335-341
• 全文大小：191KB
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• 作者单位：Valentina Rosato (1) (2)
  Cristina Bosetti (1)
  Fabio Levi (3)
  Jerry Polesel (4)
  Antonella Zucchetto (2) (4)
  Eva Negri (1)
  Carlo La Vecchia (1) (2)
  
  1. Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri- Via Giuseppe La Masa 19, 20156, Milan, Italy
  2. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
  3. Cancer Epidemiology Unit and Registre Vaudois des Tumeurs, Institut de Médecine Sociale et Préventive (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
  4. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy
  
• ISSN：1573-7225

文摘

Purpose We investigated risk factors for colorectal cancer in early-onset cancers, to provide quantitative estimates for major selected risk factors. Methods We analyzed data from three Italian and Swiss case–control studies conducted between 1985 and 2009, including 329 colorectal cancer cases and 1,361 controls aged ?5?years. We computed odds ratios (ORs) from unconditional logistic regression models, adjusted for major confounding factors. Results The OR of young-onset colorectal cancer was 4.50 for family history of colorectal cancer in first-degree relatives, the association being higher in subjects with affected siblings (OR 11.68) than parents (OR 3.75). The ORs of young-onset colorectal cancer were 1.56 for ?4 drinks/week of alcohol, 1.56 for the highest tertile of processed meat, 0.40 for vegetables, 0.75 for fruit, and 0.78 for fish intake. Among micronutrients, the ORs were 0.52 for β-carotene, 0.68 for vitamin C, 0.38 for vitamin E, and 0.59 for folate. No significant associations emerged for physical activity, overweight, and diabetes. Conclusions This study—the largest on young-onset colorectal cancer—confirms that several recognized risk factors for colorectal cancer are also relevant determinants of young-onset colorectal cancer. Family history of colorectal cancer in particular is a stronger risk factor in young subjects, as compared to middle age and elderly ones.