Giant cell myocarditis associated with amoxicillin hypersensitivity reaction

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• 作者：Soledad Martinez (1)
  Elvira Miranda (1)
  Patrick Kim (2) (3)
  Michael S. Pollanen (2) (3)
  
• 关键词：Drug hypersensitivity ; Giant cell myocarditis ; Eosinophilia ; Death
• 刊名：Forensic Science, Medicine, and Pathology
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：9
• 期：3
• 页码：403-406
• 全文大小：443KB
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• 作者单位：Soledad Martinez (1)
  Elvira Miranda (1)
  Patrick Kim (2) (3)
  Michael S. Pollanen (2) (3)
  
  1. Servicio Medico Legal, Av. La Paz 1012, Independencia, Santiago, Chile
  2. Centre for Forensic Science and Medicine, University of Toronto, Toronto, ON, Canada
  3. Ontario Forensic Pathology Service, Government of Ontario, Toronto, ON, Canada
  

文摘

We report a case of sudden unexpected death in an adult woman from florid myocarditis with necrosis, replacement fibrosis, and diffuse infiltration of the myocardium by eosinophils and conspicuous giant cells. Clinical history revealed that 3?weeks prior to death, shortly after commencing antibiotic therapy for the treatment of traumatic wound of a finger, she presented to the emergency room with a hypersensitivity reaction characterized by facial rash with edema and generalized pruritus. She was treated with antihistamines and discharged. The clinico-pathological correlation suggests a link between drug hypersensitivity and the giant cell myocarditis.