Supramolecular organizing centers (SMOCs) as signaling machines in innate immune activation
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- 作者：Qi Qiao ; Hao Wu
- 关键词：innate immunity ; caspase ; recruitment domain ; pyrin domain ; supramolecular organizing centers ; filament
- 刊名：Science China Life Sciences
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：58
- 期：11
- 页码：1067-1072
- 全文大小：1,215 KB
- 刊物主题：Life Sciences, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1869-1889
文摘
Innate immunity offers the first line of defense against infections and other types of danger such as tumorigenesis. Its discovery provides tremendous therapeutic opportunities for numerous human diseases. Delving into the structural basis of signal transduction by innate immune receptors, our lab has recently helped to establish the new paradigm in which innate immune receptors transduce ligand-binding signals through formation of higher-order assemblies containing intracellular adapters, signaling enzymes and their substrates. These large signalosome assemblies may be visible under light microscopy as punctate structures in the µm scale, connecting to the underlying molecular structures in the nm scale. They drive proximity-induced enzyme activation, and provide a mechanism for signaling amplification by nucleated polymerization. These supramolecular signaling complexes also open new questions on their cellular organization and mode of regulation, pose challenges to our methodology, and afford valuable implications in drug discovery against these medically important pathways.