Plasma ghrelin levels and polymorphisms of ghrelin gene in Chinese obese children and adolescents

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• 作者：J. F. Zhu (1)
  L. Liang (1)
  C. C. Zou (1)
  J. F. Fu (1)
  
• 关键词：Ghrelin ; Obesity ; Children ; Adolescents ; Leu72Met ; Polymorphism
• 刊名：Irish Journal of Medical Science
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：179
• 期：3
• 页码：345-349
• 全文大小：185KB
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• 作者单位：J. F. Zhu (1)
  L. Liang (1)
  C. C. Zou (1)
  J. F. Fu (1)
  
  1. Department of Endocrinology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, China
  

文摘

Aim To evaluate the role of fasting plasma ghrelin levels [ln(ghrelin)] and polymorphisms of ghrelin gene in Chinese obese children. Methods Genotyping for ghrelin polymorphism was performed in 230 obese and 100 normal weight children. Among them, plasma ghrelin levels were measured in 91 obese and 23 health subjects. Results (1) Bivariate correlation analysis showed the ln(ghrelin) was inversely correlated with abnormality of glucose metabolism (r?=??.240, P?=?0.023). Stepwise multiple regression analysis showed that abnormality of glucose metabolism was an independent determinant of plasma ghrelin levels (P?=?0.023). (2) There was no difference in frequency of Leu72Met polymorphisms between obese and control groups (36.09 vs. 41.00%). Conclusion Ghrelin is associated with obesity in childhood, especially associated with the glucose homeostasis. Lower ghrelin levels might be a result of obesity, but not a cause of obesity. The Leu72Met polymorphism of ghrelin gene is not associated with obesity and metabolic syndrome in Chinese children.