Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study
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- 作者：Manar M. Fathy ; Hosam F. Elsaadany ; Yasser F. Ali…
- 关键词：Juvenile idiopathic arthritis ; Gene polymorphisms ; Cytokines ; Interleukin ; 10
- 刊名：Italian Journal of Pediatrics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1-supp
- 全文大小：417KB
- 刊物主题：Pediatrics; Maternal and Child Health;
- 出版者：BioMed Central
- ISSN：1824-7288
- 卷排序：43
文摘
BackgroundJuvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children worldwide. Among anti-inflammatory cytokines, interleukin-10 (IL-10) is a key immunosuppressive cytokine involved in the pathogenesis of JIA. To date, only a few studies concerned the association of interleukin-10 gene polymorphisms with JIA. In this study, we aimed to investigate 3 cytokine single-nucleotide polymorphisms situated at positions -1082(G/A), −819(C/T), and −592(C/A) in the promoter region of the IL-10 gene to determine whether this polymorphism could be a marker of susceptibility to JIA in Egyptian children and adolescents. We also measured the serum level of IL-10 to assess its relation to such polymorphism.