Polymorphisms in Beta-2 Adrenergic Receptor Gene and Association with Tuberculosis

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• 作者：Abbas Farzin Azar ; Nima Hosseini Jazani ; Ahad Bazmani ; Ali Vahhabi ; Shahram Shahabi
• 关键词：Genetic susceptibility ; rs1042713 ; rs1042714 ; Single ; nucleotide polymorphisms ; Genotype
• 刊名：Lung
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：195
• 期：1
• 页码：147-153
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pneumology/Respiratory System;
• 出版者：Springer US
• ISSN：1432-1750
• 卷排序：195

文摘

PurposeGenetic susceptibility for tuberculosis in human has been previously demonstrated. Polymorphisms in genes involved in immune responses may alter the susceptibility of individuals to tuberculosis. Polymorphisms of beta-2 adrenergic receptor (ADRB2) gene can be possibly an important risk factor in tuberculosis. In this study, the association between rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene and tuberculosis was evaluated.