Influence of polymer coating on release of l-dopa from core-shell Fe@Au nanoparticle systems

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• 作者：Sulalit Bandyopadhyay ; Muhammad Awais Ashfaq Alvi…
• 关键词：Core ; shell nanoparticles ; l ; dopa ; Thermoresponse ; Microgels ; Fe@Au ; PNIPAAM
• 刊名：Colloid and Polymer Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：295
• 期：2
• 页码：391-402
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Food Science; Nanotechnology and Microengineering;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1536
• 卷排序：295

文摘

We report on the effect of different stimuli-responsive polymer shells on Fe@Au core-shell nanoparticles (NPs) with respect to thermoresponse as well as loading and release characteristics. The hybrid NP systems were investigated using a wide array of characterization techniques including dynamic light scattering, electrophoretic mobility, UV-visible spectroscopy, and scanning transmission electron microscopy. Three different polymeric shells were selected for loading and release of l-dopa: thiolated polyethylene glycol (PEG), poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAM_AAc) microgel crosslinked with N,N′-methylenebis(acrylamide) (BIS), and finally concomitant PEG and PNIPAAM_AAc microgel (Fe@Au_PEG_Microgel). All three shells were found to exhibit high loading (∼10%) and encapsulation efficiencies up to 100 μg l-dopa/mg. Although the loading efficiencies are comparable for the three systems, Fe@Au_PEG_Microgel has the highest release (87%) at elevated temperature and acidic conditions. The attenuated release from the PEG-based systems can be attributed to stronger dipole-dipole interactions between the carboxyl group of PEG and the amino group of l-dopa.