Arzneimittelnebenwirkungen im Alter

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• 作者：Dr. D. Kratzsch ; J.-C. Simon ; R. Treudler
• 关键词：Arzneimittelinteraktionen ; Geriatrische Dermatologie ; Pharmakotherapie ; Pharmakodynamik ; Polypharmazie ; Drug interactions ; Geriatric dermatology ; Pharmacotherapy ; Pharmacokinetics ; Polypharmacy
• 刊名：Der Hautarzt
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：67
• 期：2
• 页码：125-131
• 全文大小：464 KB
• 参考文献：1.Kratzsch D, Treudler R (2014) Dermatologic therapy in geriatric patients. J Dtsch Dermatol Ges 12(8):653–663PubMed
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• 作者单位：Dr. D. Kratzsch (1)
  J.-C. Simon (1)
  R. Treudler (1)
  
  1. Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Philipp-Rosenthal-Straße 23, 04103, Leipzig, Deutschland
  
• 刊物主题：Dermatology; Immunology; Allergology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1173

文摘

Pharmacotherapy in the elderly represents a challenge for dermatologists in regard to comorbidities, drug interactions, and compliance. Age-associated multimorbidity often results in polypharmacy and elevates the risk of adverse drug reactions. Crucial age-related alterations in pharmacokinetics must be considered when selecting drugs, particularly decreased total body water, altered proportion between muscle mass and adipose tissue, as well as decreased renal function. The purpose of this review is to help the reader identify relevant adverse drug reactions of often prescribed systemic dermatological pharmacons in geriatric patients and makes recommendations for their adequate application. Keywords Drug interactions Geriatric dermatology Pharmacotherapy Pharmacokinetics Polypharmacy