Endoscopic sinus surgery in adult patients with chronic rhinosinusitis with nasal polyps (PolypESS): study protocol for a randomised controlled trial
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- 作者：Evelijn S. Lourijsen ; Corianne A. J. M. de Borgie ; Marleen Vleming…
- 关键词：Sinusitis ; Nasal polyps ; Chronic disease ; Surgery ; Endoscopy ; Endoscopic surgical procedure ; Drug therapy ; Outcome ; Quality of life ; Cost ; effectiveness analysis
- 刊名：Trials
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：641KB
- 刊物主题：Medicine/Public Health, general; Biomedicine, general; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1745-6215
- 卷排序：18
文摘
BackgroundChronic rhinosinusitis with nasal polyps is a chronic disease frequently seen in otorhinolaryngological practice. Along with its chronic disease burden it creates high societal costs. Therapy consists of long-term use of medication and, if insufficient, endoscopic sinus surgery. No consensus exists on the right timing and extent of disease that warrants surgery. Furthermore, there is lack of clinical knowledge about the benefit of surgery over medication only. The current trial evaluates the clinical effectiveness and cost-effectiveness of endoscopic sinus surgery in addition to drug treatment versus medication exclusively in the adult patient group with nasal polyps.