Solid-Phase Synthesis and Catalytic Screening of Polystyrene Supported Diphosphines

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• 作者：M. C. Samuels ; F. J. L. Heutz ; A. Grabulosa ; P. C. J. Kamer
• 关键词：Solid ; phase synthesis ; Asymmetric catalysis ; Combinatorial chemistry ; P ligands ; Catalyst immobilisation
• 刊名：Topics in Catalysis
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：19-20
• 页码：1793-1799
• 全文大小：688KB
• 刊物主题：Catalysis; Physical Chemistry; Pharmacy; Industrial Chemistry/Chemical Engineering; Characterization and Evaluation of Materials;
• 出版者：Springer US
• ISSN：1572-9028
• 卷排序：59

文摘

An efficient modular method towards the synthesis of a library of polystyrene supported diphosphine ligands by combining solid-phase synthesis with rational ligand design has been developed. These supported ligands, obtained in quantitative yield, were efficiently and effectively screened in Rh-catalysed asymmetric hydrogenation of several benchmark substrates.