Synthesis of Aryl- and Pyridinyl-substituted 2-Amino-6-thioxopyridine-3-carbonitrile Derivatives by Tandem Michael Addition and Cyclization Reactions

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• 关键词：RNA folding kinetics ; Co ; transcriptional folding ; Folding pathway ; Metastable structures.
• 刊名：Monatshefte für Chemie / Chemical Monthly
• 出版年：2006
• 出版时间：March, 2006
• 年：2006
• 卷：137
• 期：3
• 页码：347-355
• 全文大小：166.0 KB

文摘

The tandem Michael addition and cyclization of 2-, 3-, and (4-pyridinylcarbonyl) thioacetanilides with arylidenemalononitriles yielded polysubstituted pyridines and bipyridines. Tetrahydro-6-thioxopyridine-3-carbonitrile was dehydrogenated to its dihydro derivative by means of HgO or DBU. The reaction of enamines of 3-, and (4-pyridinylcarbonyl)thioacetanilides with malononitrile furnished 3,4′- and 4,4′-bipyridines.