Association of hypertension with coronary artery disease onset in the Lebanese population

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• 作者：Aline Milane ; Jad Abdallah ; Roy Kanbar ; Georges Khazen…
• 关键词：Hypertension ; Coronary artery disease (CAD) ; Risk factors ; Antihypertensive drugs ; Therapeutic lifestyle changes ; Lebanese population
• 刊名：SpringerPlus
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：3
• 期：1
• 全文大小：425KB
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• 作者单位：Aline Milane (4)
  Jad Abdallah (4)
  Roy Kanbar (4)
  Georges Khazen (5)
  Michella Ghassibe-Sabbagh (6)
  Angelique K Salloum (6)
  Sonia Youhanna (6)
  Aline Saad (4)
  Hamid El Bayeh (6)
  Elie Chammas (6)
  Daniel E Platt (7)
  J枚rg Hager (8)
  Dominique Gauguier (10) (9)
  Pierre Zalloua (11) (6)
  Antoine Abchee (12)
  FGENTCARD Consortium
  
  4. Lebanese American University, School of Pharmacy, Byblos 36, Lebanon
  5. School of Arts and Sciences, Lebanese American University, Byblos 36, Lebanon
  6. School of Medicine, Lebanese American University, Beirut, 1102 2801, Lebanon
  7. Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown Hgts, NY, 10598, USA
  8. CEA-Genomics Institute, Centre National de G茅notypage, Evry, 91057, France
  10. INSERM UMRS872, Centre de Recherche des Cordeliers, 15 Rue de l鈥櫭ヽole de M茅decine, Paris, 75006, France
  9. The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
  11. Harvard School of Public Health, Boston, MA, 02215, USA
  12. Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n鈥?鈥?,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p鈥?lt;鈥?.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms. Keywords Hypertension Coronary artery disease (CAD) Risk factors Antihypertensive drugs Therapeutic lifestyle changes Lebanese population